Natural history of spheno-orbital meningiomas

Peerooz Saeed*, Wouter R. van Furth, Michael W Tanck, Fabio Kooremans, Nicole Freling, Geert I. Streekstra, Noortje I. Regensburg, Jan Willem Berkelbach van der Sprenkel, Saskia M. Peerdeman, Jakobus J. van Overbeeke, Maarten P. Mourits

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. The median follow-up for the entire group was 4 years (range, 1-15); the mean age was 47.8 (range, 26-93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm(3)/year (range, 0.03-1.8 cm(3)/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate. SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a "wait and see" policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (> 1cm(3)/year), a follow-up examination every 6 months is indicated.
Original languageEnglish
Pages (from-to)395-402
JournalActa Neurochirurgica
Issue number2
Publication statusPublished - Feb 2011


  • Spheno-orbital meningiomas
  • Orbital meningiomas
  • Natural history
  • Volumetry
  • Imaging
  • Orbitaltumors

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