TY - JOUR
T1 - Natural history of spheno-orbital meningiomas
AU - Saeed, Peerooz
AU - van Furth, Wouter R.
AU - Tanck, Michael W
AU - Kooremans, Fabio
AU - Freling, Nicole
AU - Streekstra, Geert I.
AU - Regensburg, Noortje I.
AU - van der Sprenkel, Jan Willem Berkelbach
AU - Peerdeman, Saskia M.
AU - van Overbeeke, Jakobus J.
AU - Mourits, Maarten P.
PY - 2011/2
Y1 - 2011/2
N2 - To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. The median follow-up for the entire group was 4 years (range, 1-15); the mean age was 47.8 (range, 26-93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm(3)/year (range, 0.03-1.8 cm(3)/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate. SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a "wait and see" policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (> 1cm(3)/year), a follow-up examination every 6 months is indicated.
AB - To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. The median follow-up for the entire group was 4 years (range, 1-15); the mean age was 47.8 (range, 26-93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm(3)/year (range, 0.03-1.8 cm(3)/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate. SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a "wait and see" policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (> 1cm(3)/year), a follow-up examination every 6 months is indicated.
KW - Spheno-orbital meningiomas
KW - Orbital meningiomas
KW - Natural history
KW - Volumetry
KW - Imaging
KW - Orbitaltumors
U2 - 10.1007/s00701-010-0878-0
DO - 10.1007/s00701-010-0878-0
M3 - Article
C2 - 21120550
SN - 0001-6268
VL - 153
SP - 395
EP - 402
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 2
ER -