Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

K. Verboven, D. Hansen, J. W. E. Jocken, E. E. Blaak*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)

Abstract

Natriuretic peptides have long been known for their cardiovascular function. However, a growing body of evidence emphasizes the role of natriuretic peptides in human substrate and energy metabolism, thereby connecting the heart with several insulin-sensitive organs like adipose tissue, skeletal muscle and liver. Obesity may be associated with an impaired regulation of the natriuretic peptide system, also indicated as a natriuretic handicap. Evidence points towards a contribution of this natriuretic handicap to the development of obesity, type 2 diabetes mellitus and cardiometabolic complications, although the causal relationship is not fully understood. Nevertheless, targeting the natriuretic peptide pathway may improve metabolic health in obesity and type 2 diabetes mellitus. This review will focus on current literature regarding the metabolic roles of natriuretic peptides with emphasis on lipid metabolism and insulin sensitivity. Furthermore, it will be discussed how exercise and lifestyle intervention may modulate the natriuretic peptide-related metabolic effects.

Original languageEnglish
Pages (from-to)1243-1259
Number of pages17
JournalObesity Reviews
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Insulin resistance
  • lipid metabolism
  • natriuretic peptides
  • BROWN ADIPOSE-TISSUE
  • GASTRIC BYPASS-SURGERY
  • ANGIOTENSIN-CONVERTING ENZYME
  • LEFT-VENTRICULAR DYSFUNCTION
  • CONGESTIVE-HEART-FAILURE
  • FATTY LIVER-DISEASE
  • HUMAN ADIPOCYTES
  • SKELETAL-MUSCLE
  • GENE-EXPRESSION
  • OBESE-PATIENTS

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