Nationwide treatment and outcomes of intrahepatic cholangiocarcinoma

Pim B. Olthof*, Stijn Franssen, Anne Marleen van Keulen, Lydia G. van der Geest, Frederik J.H. Hoogwater, Minneke Coenraad, Lydi M.J.W. van Driel, Joris I. Erdmann, Nadia H. Mohammad, Lara Heij, Heinz Josef Klümpen, Eric Tjwa, Liselot Valkenburg-van Iersel, Joanne Verheij, Bas Groot Koerkamp, Dutch Hepatocellular & Cholangiocarcinoma Group (DHCG)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Most data on the treatment and outcomes of intrahepatic cholangiocarcinoma (iCCA) derives from expert centers. This study aimed to investigate the treatment and outcomes of all patients diagnosed with iCCA in a nationwide cohort. Methods: Data on all patients diagnosed with iCCA between 2010 and 2018 were obtained from the Netherlands Cancer Registry. Results: In total, 1747 patients diagnosed with iCCA were included. Resection was performed in 292 patients (17%), 548 patients (31%) underwent palliative systemic treatment, and 867 patients (50%) best supportive care (BSC). The OS median and 1-, and 3-year OS were after resection: 37.5 months (31.0–44.0), 79.2%, and 51.6%,; with systemic therapy, 10.0 months (9.2–10.8), 38.4%, and 5.1%, and with BSC 2.2 months (2.0–2.5), 10.4%, and 1.3% respectively. The resection rate for patients who first presented in academic centers was 33% (96/292) compared to 13% (195/1454) in non-academic centers (P < 0.001). Discussion: Half of almost 1750 patients with iCCA over an 8 year period did not receive any treatment with a 1-year OS of 10.4%. Three-year survival was about 50% after resection, while long-term survival was rare after palliative treatment. The resection rate was higher in academic centers compared to non-academic centers.
Original languageEnglish
Pages (from-to)1329-1336
Number of pages8
JournalHPB
Volume25
Issue number11
Early online date1 Jan 2023
DOIs
Publication statusPublished - Nov 2023

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