Nasal Carriage of Streptococcus pneumoniae serotypes and Staphylococcus aureus in Streptococcus pneumoniae-vaccinated and non-vaccinated young children

N.H.T.M. Dukers-Muijrers, E. Stobberingh, P. Beisser, R.C.H. Boesten, P. Jacobs, C.J.P.A. Hoebe

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Since the implementation of Streptococcus pneumoniae (SPn) conjugate vaccination (PCV), non-vaccine types have prevailed in invasive pneumococcal disease (IPD), and an increase in Staphylococcus aureus (SA) burden has been suggested. Here, we assess the epidemiology of SA and SPn nasal carriage in 620 children at day-care centres; 141 of these children had received 1-4 PCV7 doses. A higher vaccine dosage was associated with non-vaccine-type SPn carriage. Of all SPn isolates, 45% were PCV7 types, 1% were additional PCV10 types and 22% were the three additional PCV13 types. SA carriage was inversely associated with vaccine-type SPn carriage. SPn serotype 19A showed higher SA co-carriage rates compared to other SPn serotypes. PCV7 implementation does not prevent children from being part of the IPD-related SPn transmission chain. These results contribute to the monitoring of SA-and SPn-related disease and add to the debate on the current national vaccination policy that recently included a change from PCV7 to PCV10.

Original languageEnglish
Pages (from-to)631-638
Number of pages8
JournalEpidemiology and Infection
Volume141
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Antibiotic resistance
  • children
  • day-care centres
  • Staphylococcus aureus
  • Streptococcus pneumoniae
  • vaccination
  • PNEUMOCOCCAL CONJUGATE VACCINE
  • CONTROLLED-TRIAL
  • CO-COLONIZATION
  • ASSOCIATION
  • DISEASE
  • NETHERLANDS
  • PREVENTION
  • AGE
  • REPLACEMENT
  • BACTERIAL

Cite this

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title = "Nasal Carriage of Streptococcus pneumoniae serotypes and Staphylococcus aureus in Streptococcus pneumoniae-vaccinated and non-vaccinated young children",
abstract = "Since the implementation of Streptococcus pneumoniae (SPn) conjugate vaccination (PCV), non-vaccine types have prevailed in invasive pneumococcal disease (IPD), and an increase in Staphylococcus aureus (SA) burden has been suggested. Here, we assess the epidemiology of SA and SPn nasal carriage in 620 children at day-care centres; 141 of these children had received 1-4 PCV7 doses. A higher vaccine dosage was associated with non-vaccine-type SPn carriage. Of all SPn isolates, 45{\%} were PCV7 types, 1{\%} were additional PCV10 types and 22{\%} were the three additional PCV13 types. SA carriage was inversely associated with vaccine-type SPn carriage. SPn serotype 19A showed higher SA co-carriage rates compared to other SPn serotypes. PCV7 implementation does not prevent children from being part of the IPD-related SPn transmission chain. These results contribute to the monitoring of SA-and SPn-related disease and add to the debate on the current national vaccination policy that recently included a change from PCV7 to PCV10.",
keywords = "Antibiotic resistance, children, day-care centres, Staphylococcus aureus, Streptococcus pneumoniae, vaccination, PNEUMOCOCCAL CONJUGATE VACCINE, CONTROLLED-TRIAL, CO-COLONIZATION, ASSOCIATION, DISEASE, NETHERLANDS, PREVENTION, AGE, REPLACEMENT, BACTERIAL",
author = "N.H.T.M. Dukers-Muijrers and E. Stobberingh and P. Beisser and R.C.H. Boesten and P. Jacobs and C.J.P.A. Hoebe",
year = "2013",
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language = "English",
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Nasal Carriage of Streptococcus pneumoniae serotypes and Staphylococcus aureus in Streptococcus pneumoniae-vaccinated and non-vaccinated young children. / Dukers-Muijrers, N.H.T.M.; Stobberingh, E.; Beisser, P.; Boesten, R.C.H.; Jacobs, P.; Hoebe, C.J.P.A.

In: Epidemiology and Infection, Vol. 141, No. 3, 03.2013, p. 631-638.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Nasal Carriage of Streptococcus pneumoniae serotypes and Staphylococcus aureus in Streptococcus pneumoniae-vaccinated and non-vaccinated young children

AU - Dukers-Muijrers, N.H.T.M.

AU - Stobberingh, E.

AU - Beisser, P.

AU - Boesten, R.C.H.

AU - Jacobs, P.

AU - Hoebe, C.J.P.A.

PY - 2013/3

Y1 - 2013/3

N2 - Since the implementation of Streptococcus pneumoniae (SPn) conjugate vaccination (PCV), non-vaccine types have prevailed in invasive pneumococcal disease (IPD), and an increase in Staphylococcus aureus (SA) burden has been suggested. Here, we assess the epidemiology of SA and SPn nasal carriage in 620 children at day-care centres; 141 of these children had received 1-4 PCV7 doses. A higher vaccine dosage was associated with non-vaccine-type SPn carriage. Of all SPn isolates, 45% were PCV7 types, 1% were additional PCV10 types and 22% were the three additional PCV13 types. SA carriage was inversely associated with vaccine-type SPn carriage. SPn serotype 19A showed higher SA co-carriage rates compared to other SPn serotypes. PCV7 implementation does not prevent children from being part of the IPD-related SPn transmission chain. These results contribute to the monitoring of SA-and SPn-related disease and add to the debate on the current national vaccination policy that recently included a change from PCV7 to PCV10.

AB - Since the implementation of Streptococcus pneumoniae (SPn) conjugate vaccination (PCV), non-vaccine types have prevailed in invasive pneumococcal disease (IPD), and an increase in Staphylococcus aureus (SA) burden has been suggested. Here, we assess the epidemiology of SA and SPn nasal carriage in 620 children at day-care centres; 141 of these children had received 1-4 PCV7 doses. A higher vaccine dosage was associated with non-vaccine-type SPn carriage. Of all SPn isolates, 45% were PCV7 types, 1% were additional PCV10 types and 22% were the three additional PCV13 types. SA carriage was inversely associated with vaccine-type SPn carriage. SPn serotype 19A showed higher SA co-carriage rates compared to other SPn serotypes. PCV7 implementation does not prevent children from being part of the IPD-related SPn transmission chain. These results contribute to the monitoring of SA-and SPn-related disease and add to the debate on the current national vaccination policy that recently included a change from PCV7 to PCV10.

KW - Antibiotic resistance

KW - children

KW - day-care centres

KW - Staphylococcus aureus

KW - Streptococcus pneumoniae

KW - vaccination

KW - PNEUMOCOCCAL CONJUGATE VACCINE

KW - CONTROLLED-TRIAL

KW - CO-COLONIZATION

KW - ASSOCIATION

KW - DISEASE

KW - NETHERLANDS

KW - PREVENTION

KW - AGE

KW - REPLACEMENT

KW - BACTERIAL

U2 - 10.1017/S095026881200115X

DO - 10.1017/S095026881200115X

M3 - Article

VL - 141

SP - 631

EP - 638

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 3

ER -