TY - JOUR
T1 - Nandrolone decanoate administration does not attenuate muscle atrophy during a short period of disuse
AU - Horstman, Astrid M. H.
AU - Backx, Evelien M. P.
AU - Smeets, Joey S. J.
AU - Marzuca-Nassr, Gabriel N.
AU - van Kranenburg, Janneau
AU - de Boer, Douwe
AU - Dolmans, John
AU - Snijders, Tim
AU - Verdijk, Lex B.
AU - de Groot, Lisette C. P. G. M.
AU - van Loon, Luc J. C.
N1 - Funding Information:
The author(s) received no specific funding for this work. We acknowledge the enthusiastic support of the subjects who volunteered to participate in this experiment. We greatly appreciate the expertise of the staff in the casting room and Central Diagnostic Laboratory of the MUMC+.
Publisher Copyright:
© 2019 Horstman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/1/28
Y1 - 2019/1/28
N2 - BackgroundA few days of bed rest or immobilization following injury, disease, or surgery can lead to considerable loss of skeletal muscle mass and strength. It has been speculated that such short, successive periods of muscle disuse may be largely responsible for the age-related loss of muscle mass throughout the lifespan.ObjectiveTo assess whether a single intramuscular injection of nandrolone decanoate prior to immobilization can attenuate the loss of muscle mass and strength in vivo in humans.Design, setting and participantsThirty healthy (22 +/- 1 years) men were subjected to 7 days of one-legged knee immobilization by means of a full leg cast with (NAD, n = 15) or without (CON, n = 15) prior intramuscular nandrolone decanoate injection (200 mg).MeasuresBefore and immediately after immobilization, quadriceps muscle cross-sectional area (CSA) (by means of single-slice computed tomography (CT) scans of the upper leg) and one-legged knee extension strength (one-repetition maximum [1-RM]) were assessed for both legs. Furthermore, muscle biopsies from the immobilized leg were taken before and after immobilization to assess type I and type II muscle fiber cross-sectional area.ResultsQuadriceps muscle CSA decreased during immobilization in both CON and NAD (-6 +/- 1% and -6 +/- 1%, respectively; main effect of time P<0.01), with no differences between the groups (time x treatment interaction, P = 0.59). Leg muscle strength declined following immobilization (-6 +/- 2% in CON and -7 +/- 3% in NAD; main effect of time, P<0.05), with no differences between groups (time x treatment interaction, P = 0.55).ConclusionsThis is the first study to report that nandrolone decanoate administration does not preserve skeletal muscle mass and strength during a short period of leg immobilization in vivo in humans.
AB - BackgroundA few days of bed rest or immobilization following injury, disease, or surgery can lead to considerable loss of skeletal muscle mass and strength. It has been speculated that such short, successive periods of muscle disuse may be largely responsible for the age-related loss of muscle mass throughout the lifespan.ObjectiveTo assess whether a single intramuscular injection of nandrolone decanoate prior to immobilization can attenuate the loss of muscle mass and strength in vivo in humans.Design, setting and participantsThirty healthy (22 +/- 1 years) men were subjected to 7 days of one-legged knee immobilization by means of a full leg cast with (NAD, n = 15) or without (CON, n = 15) prior intramuscular nandrolone decanoate injection (200 mg).MeasuresBefore and immediately after immobilization, quadriceps muscle cross-sectional area (CSA) (by means of single-slice computed tomography (CT) scans of the upper leg) and one-legged knee extension strength (one-repetition maximum [1-RM]) were assessed for both legs. Furthermore, muscle biopsies from the immobilized leg were taken before and after immobilization to assess type I and type II muscle fiber cross-sectional area.ResultsQuadriceps muscle CSA decreased during immobilization in both CON and NAD (-6 +/- 1% and -6 +/- 1%, respectively; main effect of time P<0.01), with no differences between the groups (time x treatment interaction, P = 0.59). Leg muscle strength declined following immobilization (-6 +/- 2% in CON and -7 +/- 3% in NAD; main effect of time, P<0.05), with no differences between groups (time x treatment interaction, P = 0.55).ConclusionsThis is the first study to report that nandrolone decanoate administration does not preserve skeletal muscle mass and strength during a short period of leg immobilization in vivo in humans.
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - SKELETAL-MUSCLE
KW - ANABOLIC-STEROIDS
KW - LEG IMMOBILIZATION
KW - OLDER-ADULTS
KW - BED-REST
KW - MASS
KW - STRENGTH
KW - HEALTHY
KW - 19-NORTESTOSTERONE
U2 - 10.1371/journal.pone.0210823
DO - 10.1371/journal.pone.0210823
M3 - Article
C2 - 30689637
SN - 1932-6203
VL - 14
SP - 1
EP - 15
JO - PLOS ONE
JF - PLOS ONE
IS - 1
M1 - e0210823
ER -