NAD(+) metabolism as a target for metabolic health: have we found the silver bullet?

Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Citations (Web of Science)

Abstract

NAD(+) has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, NAD(+) has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the NAD(+)/SIRT axis have triggered an increased interest in NAD(+) as an enhancer of energy metabolism. As a result, a myriad of publications have focused on NAD(+) metabolism, with the majority of the work having been performed using in vitro models, and in vivo work largely consisting of interventions in Caenorhabditis elegans and rodents. Human intervention trials, on the other hand, are scarce. The aim of this review is to provide an overview of the state-of-the-art on influencing NAD(+) metabolism in humans and to set the stage for what the future of this exciting field may hold.

Original languageEnglish
Pages (from-to)888-899
Number of pages12
JournalDiabetologia
Volume62
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Diabetes
  • Energy metabolism
  • Human
  • Metabolic disease
  • NAD(+)
  • Review
  • FATTY LIVER-DISEASE
  • SKELETAL-MUSCLE
  • NICOTINIC-ACID
  • MITOCHONDRIAL-FUNCTION
  • THERAPEUTIC TARGET
  • INSULIN-RESISTANCE
  • SIRT1
  • IMPROVES
  • EXERCISE
  • PHARMACOKINETICS

Cite this