Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure

Chandan K Nagaraju, Emma L Robinson, Mouna Abdesselem, Sander Trenson, Eef Dries, Guillaume Gilbert, Stefan Janssens, Johan Van Cleemput, Filip Rega, Bart Meyns, H Llewelyn Roderick, Ronald B Driesen, Karin R Sipido

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2267-2282
Number of pages16
JournalJournal of the American College of Cardiology
Volume73
Issue number18
DOIs
Publication statusPublished - 14 May 2019
Externally publishedYes

Keywords

  • Cell Adhesion Molecules/analysis
  • Cell Differentiation
  • Cells, Cultured
  • Disease Progression
  • Fibroblasts/metabolism
  • Fibrosis
  • Heart Failure/metabolism
  • Humans
  • Immunohistochemistry
  • Myocardium/metabolism
  • Myofibroblasts/metabolism
  • Osteopontin/analysis
  • Protein-Lysine 6-Oxidase/analysis
  • Signal Transduction
  • Transforming Growth Factor beta1/analysis
  • Ventricular Dysfunction/etiology
  • HYPERTROPHY
  • fibroblasts
  • INHIBITION
  • inflammation
  • DYSFUNCTION
  • contractile function
  • MYOCARDIAL-INFARCTION
  • FIBROBLASTS
  • GROWTH-FACTOR-BETA
  • CARDIAC FIBROSIS
  • extracellular matrix

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