Insulin resistance lies at the basis of type 2 diabetes. Insulin resistance is often paired with increased fat deposits in muscle tissue, which some people claim to be the cause; however, highly trained and insulin-sensitive athletes also store a lot of fat in their muscles, which serves to counter this causal relationship. This dissertation examines the distinct characteristics of fat accumulation in insulin-sensitive and insulin-resistant states using techniques such as microscopy. The most important conclusion is that normal lipid droplets that come into contact with the protein PLIN5 are associated with higher insulin sensitivity.
|Award date||24 May 2017|
|Place of Publication||Maastricht|
|Publication status||Published - 2017|
- type 2 diabetes
- insulin resistance
- fat accumulation in muscles