Myocellular lipid droplets and insulin sensitivity: a microscopy approach

Research output: ThesisDoctoral ThesisInternal

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Abstract

Insulin resistance lies at the basis of type 2 diabetes. Insulin resistance is often paired with increased fat deposits in muscle tissue, which some people claim to be the cause; however, highly trained and insulin-sensitive athletes also store a lot of fat in their muscles, which serves to counter this causal relationship. This dissertation examines the distinct characteristics of fat accumulation in insulin-sensitive and insulin-resistant states using techniques such as microscopy. The most important conclusion is that normal lipid droplets that come into contact with the protein PLIN5 are associated with higher insulin sensitivity.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Hesselink, Matthijs, Supervisor
  • Schrauwen, Patrick, Supervisor
  • van Zandvoort, Marc, Advisor
Award date24 May 2017
Place of PublicationMaastricht
Publisher
Print ISBNs9789462336155
DOIs
Publication statusPublished - 2017

Keywords

  • type 2 diabetes
  • insulin resistance
  • fat accumulation in muscles

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