Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective

Milica M.Labudovic Borovic; Milan M. Obradovic; Jelena T. Kostic; Ivan V. Zaletel; Dejan G. Milašinovic; Marija T. Stojanovic; Slavica S. Mutavdžin; Milena N. Veskovic; Dragan J. Opacic; Dejan D. Radakovic; Nela S. Puškaš; Tatjana S. Radosavljevic; Saša D. Borovic; Zvezdana Z. Kojic; Božidarka L. Zaric; Ljiljana G. Šcepanovic; Esma R. Isenovic

doi:10.1007/978-3-319-24750-2_7

Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective

Milica M.Labudovic Borovic^*
, Milan M. Obradovic
, Jelena T. Kostic^*
, Ivan V. Zaletel
, Dejan G. Milašinovic
, Marija T. Stojanovic
, Slavica S. Mutavdžin
, Milena N. Veskovic
, Dragan J. Opacic
, Dejan D. Radakovic
, Nela S. Puškaš
, Tatjana S. Radosavljevic
, Saša D. Borovic^*
, Zvezdana Z. Kojic
, Božidarka L. Zaric
, Ljiljana G. Šcepanovic
, Esma R. Isenovic

^*Corresponding author for this work

Fysiologie

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Structure and functions of Na⁺/K⁺-ATPase and SERCA are described with details on their subunits, isoforms, and intracellular localization. Main regulatory mechanisms are summarized. Molecular mechanisms of cell death and heart failure are explained with the analysis of the role of Na⁺/K⁺-ATPase and SERCA in these processes. Facts are considered from a cytological, pathological, and clinical perspective with an accent to new therapeutic strategies. The aim of this contribution is an overview of functional results in a structural context.

Original language	English
Title of host publication	Advances in Biochemistry in Health and Disease
Editors	Sajal Chakraborti, Naranjan S Dhalla
Publisher	Springer
Pages	113-144
Number of pages	32
Volume	15
Edition	1
ISBN (Electronic)	9783319796727
ISBN (Print)	9783319247489
DOIs	https://doi.org/10.1007/978-3-319-24750-2_7
Publication status	Published - 1 Jan 2016

Publication series

Series	Advances in Biochemistry in Health and Disease
Volume	15
ISSN	2512-2142

Keywords

Apoptosis
Cardiomyocytes
Cardiomyopathy
Cell injury
Heart failure
Hypertrophy
Ischemia
Na+/K+-ATPase
Necrosis
SERCA

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10.1007/978-3-319-24750-2_7

Cite this

Borovic, M. M. L., Obradovic, M. M., Kostic, J. T., Zaletel, I. V., Milašinovic, D. G., Stojanovic, M. T., Mutavdžin, S. S., Veskovic, M. N., Opacic, D. J., Radakovic, D. D., Puškaš, N. S., Radosavljevic, T. S., Borovic, S. D., Kojic, Z. Z., Zaric, B. L., Šcepanovic, L. G., & Isenovic, E. R. (2016). Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective. In S. Chakraborti, & N. S. Dhalla (Eds.), Advances in Biochemistry in Health and Disease (1 ed., Vol. 15, pp. 113-144). Springer. https://doi.org/10.1007/978-3-319-24750-2_7

Borovic, Milica M.Labudovic ; Obradovic, Milan M. ; Kostic, Jelena T. et al. / Myocardial Na+ K+-ATPase and SERCA : Clinical and Pathological Significance From a Cytological Perspective. Advances in Biochemistry in Health and Disease. editor / Sajal Chakraborti ; Naranjan S Dhalla. Vol. 15 1. ed. Springer, 2016. pp. 113-144 (Advances in Biochemistry in Health and Disease, Vol. 15).

@inbook{6d7f526777fb48cc896ebe94f04fdd52,

title = "Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective",

abstract = "Structure and functions of Na+/K+-ATPase and SERCA are described with details on their subunits, isoforms, and intracellular localization. Main regulatory mechanisms are summarized. Molecular mechanisms of cell death and heart failure are explained with the analysis of the role of Na+/K+-ATPase and SERCA in these processes. Facts are considered from a cytological, pathological, and clinical perspective with an accent to new therapeutic strategies. The aim of this contribution is an overview of functional results in a structural context.",

keywords = "Apoptosis, Cardiomyocytes, Cardiomyopathy, Cell injury, Heart failure, Hypertrophy, Ischemia, Na+/K+-ATPase, Necrosis, SERCA",

author = "Borovic, \{Milica M.Labudovic\} and Obradovic, \{Milan M.\} and Kostic, \{Jelena T.\} and Zaletel, \{Ivan V.\} and Mila{\v s}inovic, \{Dejan G.\} and Stojanovic, \{Marija T.\} and Mutavd{\v z}in, \{Slavica S.\} and Veskovic, \{Milena N.\} and Opacic, \{Dragan J.\} and Radakovic, \{Dejan D.\} and Pu{\v s}ka{\v s}, \{Nela S.\} and Radosavljevic, \{Tatjana S.\} and Borovic, \{Sa{\v s}a D.\} and Kojic, \{Zvezdana Z.\} and Zaric, \{Bo{\v z}idarka L.\} and {\v S}cepanovic, \{Ljiljana G.\} and Isenovic, \{Esma R.\}",

note = "Funding Information: The research activities were supported by grants No. 173033, 175005, 175015, 175061, III41002, III41022, III41027, and III45005 from the Ministry of Education, Science and Technological Development of Republic of Serbia and by the MedSAP Research Network Project, granted by the U.S. Embassy in Belgrade (Award Number: SRB100-15-GR-355). Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2016.",

year = "2016",

month = jan,

day = "1",

doi = "10.1007/978-3-319-24750-2\_7",

language = "English",

isbn = "9783319247489",

volume = "15",

series = "Advances in Biochemistry in Health and Disease",

publisher = "Springer",

pages = "113--144",

editor = "Sajal Chakraborti and Dhalla, \{Naranjan S\}",

booktitle = "Advances in Biochemistry in Health and Disease",

address = "United States",

edition = "1",

}

Borovic, MML, Obradovic, MM, Kostic, JT, Zaletel, IV, Milašinovic, DG, Stojanovic, MT, Mutavdžin, SS, Veskovic, MN, Opacic, DJ, Radakovic, DD, Puškaš, NS, Radosavljevic, TS, Borovic, SD, Kojic, ZZ, Zaric, BL, Šcepanovic, LG & Isenovic, ER 2016, Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective. in S Chakraborti & NS Dhalla (eds), Advances in Biochemistry in Health and Disease. 1 edn, vol. 15, Springer, Advances in Biochemistry in Health and Disease, vol. 15, pp. 113-144. https://doi.org/10.1007/978-3-319-24750-2_7

Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective. / Borovic, Milica M.Labudovic; Obradovic, Milan M.; Kostic, Jelena T. et al.
Advances in Biochemistry in Health and Disease. ed. / Sajal Chakraborti; Naranjan S Dhalla. Vol. 15 1. ed. Springer, 2016. p. 113-144 (Advances in Biochemistry in Health and Disease, Vol. 15).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

TY - CHAP

T1 - Myocardial Na+ K+-ATPase and SERCA

T2 - Clinical and Pathological Significance From a Cytological Perspective

AU - Borovic, Milica M.Labudovic

AU - Obradovic, Milan M.

AU - Kostic, Jelena T.

AU - Zaletel, Ivan V.

AU - Milašinovic, Dejan G.

AU - Stojanovic, Marija T.

AU - Mutavdžin, Slavica S.

AU - Veskovic, Milena N.

AU - Opacic, Dragan J.

AU - Radakovic, Dejan D.

AU - Puškaš, Nela S.

AU - Radosavljevic, Tatjana S.

AU - Borovic, Saša D.

AU - Kojic, Zvezdana Z.

AU - Zaric, Božidarka L.

AU - Šcepanovic, Ljiljana G.

AU - Isenovic, Esma R.

N1 - Funding Information: The research activities were supported by grants No. 173033, 175005, 175015, 175061, III41002, III41022, III41027, and III45005 from the Ministry of Education, Science and Technological Development of Republic of Serbia and by the MedSAP Research Network Project, granted by the U.S. Embassy in Belgrade (Award Number: SRB100-15-GR-355). Publisher Copyright: © Springer International Publishing Switzerland 2016.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Structure and functions of Na+/K+-ATPase and SERCA are described with details on their subunits, isoforms, and intracellular localization. Main regulatory mechanisms are summarized. Molecular mechanisms of cell death and heart failure are explained with the analysis of the role of Na+/K+-ATPase and SERCA in these processes. Facts are considered from a cytological, pathological, and clinical perspective with an accent to new therapeutic strategies. The aim of this contribution is an overview of functional results in a structural context.

AB - Structure and functions of Na+/K+-ATPase and SERCA are described with details on their subunits, isoforms, and intracellular localization. Main regulatory mechanisms are summarized. Molecular mechanisms of cell death and heart failure are explained with the analysis of the role of Na+/K+-ATPase and SERCA in these processes. Facts are considered from a cytological, pathological, and clinical perspective with an accent to new therapeutic strategies. The aim of this contribution is an overview of functional results in a structural context.

KW - Apoptosis

KW - Cardiomyocytes

KW - Cardiomyopathy

KW - Cell injury

KW - Heart failure

KW - Hypertrophy

KW - Ischemia

KW - Na+/K+-ATPase

KW - Necrosis

KW - SERCA

U2 - 10.1007/978-3-319-24750-2_7

DO - 10.1007/978-3-319-24750-2_7

M3 - Chapter

SN - 9783319247489

VL - 15

T3 - Advances in Biochemistry in Health and Disease

SP - 113

EP - 144

BT - Advances in Biochemistry in Health and Disease

A2 - Chakraborti, Sajal

A2 - Dhalla, Naranjan S

PB - Springer

ER -

Borovic MML, Obradovic MM, Kostic JT, Zaletel IV, Milašinovic DG, Stojanovic MT et al. Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective. In Chakraborti S, Dhalla NS, editors, Advances in Biochemistry in Health and Disease. 1 ed. Vol. 15. Springer. 2016. p. 113-144. (Advances in Biochemistry in Health and Disease, Vol. 15). doi: 10.1007/978-3-319-24750-2_7

Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective

Abstract

Publication series

Keywords

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