Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature

A. Korn*, U. Baylan, S. Simsek, C.G. Schalkwijk, H.W.M. Niessen, P.A.J. Krijnen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background Myocardial infarction (MI) is associated with mental health disorders, in which neuroinflammation and cerebral microvascular dysfunction may play a role. Previously, we have shown that the proinflammatory factors N-epsilon-(carboxymethyl)lysine (CML) and NADPH oxidase 2 (NOX2) are increased in the human infarcted heart microvasculature. The aim of this study was to analyse the presence of CML and NOX2 in the cerebral microvasculature of patients with MI.Methods Brain tissue was obtained at autopsy from 24 patients with MI and nine control patients. According to their infarct age, patients with MI were divided into three groups: 3-6 hours old (phase I), 6 hours-5 days old (phase II) and 5-14 days old (phase III). CML and NOX2 in the microvasculature were studied through immunohistochemical analysis.Results We observed a 2.5-fold increase in cerebral microvascular CML in patients with phase II and phase III MI (phase II: 21.39 +/- 7.91, p=0.004; phase III: 24.21 +/- 10.37, p=0.0007) compared with non-MI controls (8.55 +/- 2.98). NOX2 was increased in microvessels in patients with phase II MI (p=0.002) and phase III MI (p=0.04) compared with controls. No correlation was found between CML and NOX2 (r=0.58, p=0.13).Conclusions MI coincides with an increased presence of CML and NOX2 in the brain microvasculature. These data point to proinflammatory alterations in the brain microvasculature that may underlie MI-associated mental health disorders.
Original languageEnglish
Article numbere001842
Number of pages6
JournalOpen Heart
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • myocardial infarction
  • inflammation
  • biomarkers
  • GLYCOXIDATION PRODUCT N-EPSILON-(CARBOXYMETHYL)LYSINE
  • SMALL VESSEL DISEASE
  • BLOOD-FLOW
  • INCREASED ACCUMULATION
  • COGNITIVE FUNCTION
  • DIABETIC-PATIENTS
  • OXIDATIVE STRESS
  • HEART-FAILURE
  • INFLAMMATION
  • DEMENTIA

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