Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature

R.J. Slegers; T.A.M.B. van der Vlis; L. Ackermans; A. Hoeben; A.A. Postma; I. Compter; J.G.J. Hoeijmakers; J. Beckervordersandforth; M.P.G. Broen; O.E.M.G. Schijns

doi:10.1007/s00701-021-05035-3

Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature

R.J. Slegers^*, T.A.M.B. van der Vlis, L. Ackermans, A. Hoeben, A.A. Postma, I. Compter, J.G.J. Hoeijmakers, J. Beckervordersandforth, M.P.G. Broen, O.E.M.G. Schijns

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.

Original language	English
Pages (from-to)	423-427
Number of pages	5
Journal	Acta Neurochirurgica
Volume	164
Issue number	2
Early online date	29 Oct 2021
DOIs	https://doi.org/10.1007/s00701-021-05035-3
Publication status	Published - Feb 2022

Keywords

Myasthenia gravis
Paraneoplastic neurological syndrome
Glioblastoma
Brain tumor
Neuromuscular junction
EXTRATHYMIC MALIGNANCIES

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Slegers, R. J., van der Vlis, T. A. M. B., Ackermans, L., Hoeben, A., Postma, A. A., Compter, I., Hoeijmakers, J. G. J., Beckervordersandforth, J., Broen, M. P. G., & Schijns, O. E. M. G. (2022). Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature. Acta Neurochirurgica, 164(2), 423-427. https://doi.org/10.1007/s00701-021-05035-3

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title = "Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature",

abstract = "Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.",

keywords = "Myasthenia gravis, Paraneoplastic neurological syndrome, Glioblastoma, Brain tumor, Neuromuscular junction, EXTRATHYMIC MALIGNANCIES",

author = "R.J. Slegers and {van der Vlis}, T.A.M.B. and L. Ackermans and A. Hoeben and A.A. Postma and I. Compter and J.G.J. Hoeijmakers and J. Beckervordersandforth and M.P.G. Broen and O.E.M.G. Schijns",

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year = "2022",

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doi = "10.1007/s00701-021-05035-3",

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Slegers, RJ, van der Vlis, TAMB, Ackermans, L , Hoeben, A , Postma, AA, Compter, I, Hoeijmakers, JGJ , Beckervordersandforth, J , Broen, MPG & Schijns, OEMG 2022, 'Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature', Acta Neurochirurgica, vol. 164, no. 2, pp. 423-427. https://doi.org/10.1007/s00701-021-05035-3

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T1 - Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature

AU - Slegers, R.J.

AU - van der Vlis, T.A.M.B.

AU - Ackermans, L.

AU - Hoeben, A.

AU - Postma, A.A.

AU - Compter, I.

AU - Hoeijmakers, J.G.J.

AU - Beckervordersandforth, J.

AU - Broen, M.P.G.

AU - Schijns, O.E.M.G.

PY - 2022/2

Y1 - 2022/2

N2 - Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.

AB - Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.

KW - Myasthenia gravis

KW - Paraneoplastic neurological syndrome

KW - Glioblastoma

KW - Brain tumor

KW - Neuromuscular junction

KW - EXTRATHYMIC MALIGNANCIES

U2 - 10.1007/s00701-021-05035-3

DO - 10.1007/s00701-021-05035-3

M3 - (Systematic) Review article

C2 - 34714432

SN - 0001-6268

VL - 164

SP - 423

EP - 427

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

IS - 2

ER -

Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature

Abstract

Keywords

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