Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

M. Steklov; S. Pandolf; M. F. Baietti; A. Batiuk; P. Carai; P. Najm; M. Zhang; H. Jang; F. Renzi; Y. Cai; L. Abbasi Asbagh; T. Pastor; M. De Troyer; M. Simicek; E. Radaelli; H. Brems; E. Legius; J. Tavernier; K. Gevaert; F. Impens; L. Messiaen; R. Nussinov; S. Heymans; S. Eyekerman; A. A. Sablina

doi:10.1126/science.aap7607

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

M. Steklov, S. Pandolf, M. F. Baietti, A. Batiuk, P. Carai, P. Najm, M. Zhang, H. Jang, F. Renzi, Y. Cai, L. Abbasi Asbagh, T. Pastor, M. De Troyer, M. Simicek, E. Radaelli, H. Brems, E. Legius, J. Tavernier, K. Gevaert, F. ImpensL. Messiaen, R. Nussinov, S. Heymans, S. Eyekerman, A. A. Sablina^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1177-1182
Number of pages	6
Journal	Science
Volume	362
Issue number	6419
DOIs	https://doi.org/10.1126/science.aap7607
Publication status	Published - 7 Dec 2018

Keywords

FAST INTERACTION REFINEMENT
RARE VARIANTS
MEMBRANE
FIREDOCK
REVEALS
CHARMM

Access to Document

10.1126/science.aap7607

Cite this

Steklov, M., Pandolf, S., Baietti, M. F., Batiuk, A., Carai, P., Najm, P., Zhang, M., Jang, H., Renzi, F., Cai, Y., Asbagh, L. A., Pastor, T., De Troyer, M., Simicek, M., Radaelli, E., Brems, H., Legius, E., Tavernier, J., Gevaert, K., ... Sablina, A. A. (2018). Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. Science, 362(6419), 1177-1182. https://doi.org/10.1126/science.aap7607

Steklov, M. ; Pandolf, S. ; Baietti, M. F. ; Batiuk, A. ; Carai, P. ; Najm, P. ; Zhang, M. ; Jang, H. ; Renzi, F. ; Cai, Y. ; Asbagh, L. Abbasi ; Pastor, T. ; De Troyer, M. ; Simicek, M. ; Radaelli, E. ; Brems, H. ; Legius, E. ; Tavernier, J. ; Gevaert, K. ; Impens, F. ; Messiaen, L. ; Nussinov, R. ; Heymans, S. ; Eyekerman, S. ; Sablina, A. A. / Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. In: Science. 2018 ; Vol. 362, No. 6419. pp. 1177-1182.

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title = "Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination",

keywords = "FAST INTERACTION REFINEMENT, RARE VARIANTS, MEMBRANE, FIREDOCK, REVEALS, CHARMM",

author = "M. Steklov and S. Pandolf and Baietti, {M. F.} and A. Batiuk and P. Carai and P. Najm and M. Zhang and H. Jang and F. Renzi and Y. Cai and Asbagh, {L. Abbasi} and T. Pastor and {De Troyer}, M. and M. Simicek and E. Radaelli and H. Brems and E. Legius and J. Tavernier and K. Gevaert and F. Impens and L. Messiaen and R. Nussinov and S. Heymans and S. Eyekerman and Sablina, {A. A.}",

year = "2018",

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doi = "10.1126/science.aap7607",

language = "English",

volume = "362",

pages = "1177--1182",

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Steklov, M, Pandolf, S, Baietti, MF, Batiuk, A, Carai, P, Najm, P, Zhang, M, Jang, H, Renzi, F, Cai, Y, Asbagh, LA, Pastor, T, De Troyer, M, Simicek, M, Radaelli, E, Brems, H, Legius, E, Tavernier, J, Gevaert, K, Impens, F, Messiaen, L, Nussinov, R, Heymans, S, Eyekerman, S & Sablina, AA 2018, 'Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination', Science, vol. 362, no. 6419, pp. 1177-1182. https://doi.org/10.1126/science.aap7607

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. / Steklov, M.; Pandolf, S.; Baietti, M. F.; Batiuk, A.; Carai, P.; Najm, P.; Zhang, M.; Jang, H.; Renzi, F.; Cai, Y.; Asbagh, L. Abbasi; Pastor, T.; De Troyer, M.; Simicek, M.; Radaelli, E.; Brems, H.; Legius, E.; Tavernier, J.; Gevaert, K.; Impens, F.; Messiaen, L.; Nussinov, R.; Heymans, S.; Eyekerman, S.; Sablina, A. A.

In: Science, Vol. 362, No. 6419, 07.12.2018, p. 1177-1182.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

AU - Steklov, M.

AU - Pandolf, S.

AU - Baietti, M. F.

AU - Batiuk, A.

AU - Carai, P.

AU - Najm, P.

AU - Zhang, M.

AU - Jang, H.

AU - Renzi, F.

AU - Cai, Y.

AU - Asbagh, L. Abbasi

AU - Pastor, T.

AU - De Troyer, M.

AU - Simicek, M.

AU - Radaelli, E.

AU - Brems, H.

AU - Legius, E.

AU - Tavernier, J.

AU - Gevaert, K.

AU - Impens, F.

AU - Messiaen, L.

AU - Nussinov, R.

AU - Heymans, S.

AU - Eyekerman, S.

AU - Sablina, A. A.

PY - 2018/12/7

Y1 - 2018/12/7

KW - FAST INTERACTION REFINEMENT

KW - RARE VARIANTS

KW - MEMBRANE

KW - FIREDOCK

KW - REVEALS

KW - CHARMM

U2 - 10.1126/science.aap7607

DO - 10.1126/science.aap7607

M3 - Article

VL - 362

SP - 1177

EP - 1182

JO - Science

JF - Science

SN - 0036-8075

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ER -