Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region

Peter J Schwartz; Cristina Moreno; Maria-Christina Kotta; Matteo Pedrazzini; Lia Crotti; Federica Dagradi; Silvia Castelletti; Kristina H Haugaa; Isabelle Denjoy; Maria A Shkolnikova; Paul A Brink; Marshall J Heradien; Sandrine R M Seyen; Roel L H M G Spätjens; Carla Spazzolini; Paul G A Volders

doi:10.1093/eurheartj/ehab582

Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region

Peter J Schwartz^*, Cristina Moreno, Maria-Christina Kotta, Matteo Pedrazzini, Lia Crotti, Federica Dagradi, Silvia Castelletti, Kristina H Haugaa, Isabelle Denjoy, Maria A Shkolnikova, Paul A Brink, Marshall J Heradien, Sandrine R M Seyen, Roel L H M G Spätjens, Carla Spazzolini, Paul G A Volders

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Original language	English
Pages (from-to)	4743-4755
Number of pages	14
Journal	European Heart Journal
Volume	42
Issue number	46
Early online date	10 Sep 2021
DOIs	https://doi.org/10.1093/eurheartj/ehab582
Publication status	Published - 7 Dec 2021

Keywords

Long QT syndrome
Genetics
Sudden cardiac death
DOMINANT-NEGATIVE SUPPRESSION
LANGE-NIELSEN-SYNDROME
GENETIC MODIFIER
CHANNEL
KVLQT1
REQUIREMENT
MECHANISMS
PHENOTYPE
VARIANTS
GENOTYPE

Access to Document

10.1093/eurheartj/ehab582

Cite this

Schwartz, P. J., Moreno, C., Kotta, M-C., Pedrazzini, M., Crotti, L., Dagradi, F., Castelletti, S., Haugaa, K. H., Denjoy, I., Shkolnikova, M. A., Brink, P. A., Heradien, M. J., Seyen, S. R. M., Spätjens, R. L. H. M. G., Spazzolini, C., & Volders, P. G. A. (2021). Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region. European Heart Journal, 42(46), 4743-4755. https://doi.org/10.1093/eurheartj/ehab582

Schwartz, Peter J ; Moreno, Cristina ; Kotta, Maria-Christina ; Pedrazzini, Matteo ; Crotti, Lia ; Dagradi, Federica ; Castelletti, Silvia ; Haugaa, Kristina H ; Denjoy, Isabelle ; Shkolnikova, Maria A ; Brink, Paul A ; Heradien, Marshall J ; Seyen, Sandrine R M ; Spätjens, Roel L H M G ; Spazzolini, Carla ; Volders, Paul G A. / Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1 : the importance of the KCNQ1 S6 region. In: European Heart Journal. 2021 ; Vol. 42, No. 46. pp. 4743-4755.

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title = "Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region",

keywords = "Long QT syndrome, Genetics, Sudden cardiac death, DOMINANT-NEGATIVE SUPPRESSION, LANGE-NIELSEN-SYNDROME, GENETIC MODIFIER, CHANNEL, KVLQT1, REQUIREMENT, MECHANISMS, PHENOTYPE, VARIANTS, GENOTYPE",

author = "Schwartz, {Peter J} and Cristina Moreno and Maria-Christina Kotta and Matteo Pedrazzini and Lia Crotti and Federica Dagradi and Silvia Castelletti and Haugaa, {Kristina H} and Isabelle Denjoy and Shkolnikova, {Maria A} and Brink, {Paul A} and Heradien, {Marshall J} and Seyen, {Sandrine R M} and Sp{\"a}tjens, {Roel L H M G} and Carla Spazzolini and Volders, {Paul G A}",

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doi = "10.1093/eurheartj/ehab582",

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Schwartz, PJ, Moreno, C, Kotta, M-C, Pedrazzini, M, Crotti, L, Dagradi, F, Castelletti, S, Haugaa, KH, Denjoy, I, Shkolnikova, MA, Brink, PA, Heradien, MJ, Seyen, SRM, Spätjens, RLHMG, Spazzolini, C & Volders, PGA 2021, 'Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region', European Heart Journal, vol. 42, no. 46, pp. 4743-4755. https://doi.org/10.1093/eurheartj/ehab582

Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1 : the importance of the KCNQ1 S6 region. / Schwartz, Peter J; Moreno, Cristina; Kotta, Maria-Christina; Pedrazzini, Matteo; Crotti, Lia; Dagradi, Federica; Castelletti, Silvia; Haugaa, Kristina H; Denjoy, Isabelle; Shkolnikova, Maria A; Brink, Paul A; Heradien, Marshall J; Seyen, Sandrine R M; Spätjens, Roel L H M G; Spazzolini, Carla; Volders, Paul G A.

In: European Heart Journal, Vol. 42, No. 46, 07.12.2021, p. 4743-4755.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Schwartz, Peter J

AU - Moreno, Cristina

AU - Kotta, Maria-Christina

AU - Pedrazzini, Matteo

AU - Crotti, Lia

AU - Dagradi, Federica

AU - Castelletti, Silvia

AU - Haugaa, Kristina H

AU - Denjoy, Isabelle

AU - Shkolnikova, Maria A

AU - Brink, Paul A

AU - Heradien, Marshall J

AU - Seyen, Sandrine R M

AU - Spätjens, Roel L H M G

AU - Spazzolini, Carla

AU - Volders, Paul G A

PY - 2021/12/7

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KW - Long QT syndrome

KW - Genetics

KW - Sudden cardiac death

KW - DOMINANT-NEGATIVE SUPPRESSION

KW - LANGE-NIELSEN-SYNDROME

KW - GENETIC MODIFIER

KW - CHANNEL

KW - KVLQT1

KW - REQUIREMENT

KW - MECHANISMS

KW - PHENOTYPE

KW - VARIANTS

KW - GENOTYPE

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DO - 10.1093/eurheartj/ehab582

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JO - European Heart Journal

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