Muscle atrophy in cachexia: can dietary protein tip the balance?

C.M.H. Op den Kamp, R.C. Langen, A. Haegens, A.M. Schols

    Research output: Contribution to journalArticleAcademicpeer-review

    13 Citations (Scopus)

    Abstract

    PURPOSE OF REVIEW: To review the efficacy of dietary protein supplementation in attenuating muscle atrophy in cachexia. RECENT FINDINGS: Only very few recent randomized controlled trials have studied the effects of protein supplementation in clinical cachexia. It appears that supplementation of dietary protein (>1.5 g/kg per day) alone or in combination with other anabolic stimuli such as exercise training maintains or even improves muscle mass, but results on muscle function are controversial and no clinical studies have yet directly linked alterations in cellular signaling or metabolic signatures of protein intake-induced muscle anabolism to muscle weight gain. SUMMARY: To elucidate the role of dietary protein supplementation in attenuating muscle atrophy in cachectic patients, randomized clinical trials are needed in adequately phenotyped patients using sensitive measures of muscle mass and function.
    Original languageEnglish
    Pages (from-to)611-616
    JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
    Volume12
    Issue number6
    DOIs
    Publication statusPublished - 1 Jan 2009

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