Multisite phosphorylation in platelets stimulated via glycoprotein VI and G protein-coupled receptors: interactions and functional impact

Pengyu Zhang

doi:10.26481/dis.20240606pz

Multisite phosphorylation in platelets stimulated via glycoprotein VI and G protein-coupled receptors: interactions and functional impact

Pengyu Zhang

Research output: Thesis › Doctoral Thesis › External prepared

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Abstract

By employing a comprehensive exploration of the molecular mechanisms of human platelet activation, this thesis investigates the mechanism of platelet activation and their function, thereby contributing to advancements in platelet biology and pharmacology. The findings in this thesis will help to develop future kinase-related antiplatelet drugs for cardiovascular diseases, inflammation and cancer.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University Johannes Gutenberg-Universität Mainz
Supervisors/Advisors	Heemskerk, Johan W.M., Supervisor, External person Walter, Ulrich, Supervisor, External person Jurk, Kerstin, Co-Supervisor, External person Kuijpers, Marijke, Co-Supervisor
Award date	6 Jun 2024
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789464699432
DOIs	https://doi.org/10.26481/dis.20240606pz
Publication status	Published - 2024

Keywords

Btk
PKC
kinase inhibitor
crosstalk

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10.26481/dis.20240606pz

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Cite this

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AB - By employing a comprehensive exploration of the molecular mechanisms of human platelet activation, this thesis investigates the mechanism of platelet activation and their function, thereby contributing to advancements in platelet biology and pharmacology. The findings in this thesis will help to develop future kinase-related antiplatelet drugs for cardiovascular diseases, inflammation and cancer.

KW - Btk

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KW - kinase inhibitor

KW - crosstalk

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DO - 10.26481/dis.20240606pz

M3 - Doctoral Thesis

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ER -

Multisite phosphorylation in platelets stimulated via glycoprotein VI and G protein-coupled receptors: interactions and functional impact

Abstract

Keywords

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