Multisite phosphorylation in platelets stimulated via glycoprotein VI and G protein-coupled receptors: interactions and functional impact

Pengyu Zhang

Research output: ThesisDoctoral ThesisExternal prepared

181 Downloads (Pure)

Abstract

By employing a comprehensive exploration of the molecular mechanisms of human platelet activation, this thesis investigates the mechanism of platelet activation and their function, thereby contributing to advancements in platelet biology and pharmacology. The findings in this thesis will help to develop future kinase-related antiplatelet drugs for cardiovascular diseases, inflammation and cancer.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Johannes Gutenberg-Universität Mainz
Supervisors/Advisors
  • Heemskerk, Johan W.M., Supervisor, External person
  • Walter, Ulrich, Supervisor, External person
  • Jurk, Kerstin, Co-Supervisor, External person
  • Kuijpers, Marijke, Co-Supervisor
Award date6 Jun 2024
Place of PublicationMaastricht
Publisher
Print ISBNs9789464699432
DOIs
Publication statusPublished - 2024

Keywords

  • Btk
  • PKC
  • kinase inhibitor
  • crosstalk

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