Multiscale modeling of cardiac electrical activity

Philippe Comtois; Mark Potse; Alain Vinet

doi:10.1051/medsci/201026157

Multiscale modeling of cardiac electrical activity

Philippe Comtois, Mark Potse, Alain Vinet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Models of cardiac electrical activity cover a wide range of spatial scales, from the genesis of the ionic currents in individual cardiomyocytes to the generation of electrocardiograms on the torso. The level of detail that is appropriate and practicable depends on the problem investigated and the scope of the computations that are required. We briefly present three examples of modelling: the dynamics of the entrainment of a single cell, the impact of fibrosis on electrical propagation in a piece of tissue and the generation of ECG in human. In each case, the methods, results and limitations are discussed.

Original language	English
Pages (from-to)	57-64
Journal	M S-Medecine Sciences
Volume	26
Issue number	1
DOIs	https://doi.org/10.1051/medsci/201026157
Publication status	Published - Jan 2010

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AB - Models of cardiac electrical activity cover a wide range of spatial scales, from the genesis of the ionic currents in individual cardiomyocytes to the generation of electrocardiograms on the torso. The level of detail that is appropriate and practicable depends on the problem investigated and the scope of the computations that are required. We briefly present three examples of modelling: the dynamics of the entrainment of a single cell, the impact of fibrosis on electrical propagation in a piece of tissue and the generation of ECG in human. In each case, the methods, results and limitations are discussed.

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Multiscale modeling of cardiac electrical activity

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