Multiple pathologies in dementia : correlations with clinical diagnoses

C. Echávarri Zalba

Research output: ThesisDoctoral ThesisInternal

177 Downloads (Pure)


The research focused on patients with dementia for whom the cognitive impairment interfered with their daily life. Dementia was studied from a neuropathological point of view. The materials used for this research were brains of deceased patients with dementia. According to the predominant pathology found, different subtypes of dementia (Alzheimer´s disease, vascular dementia, Lewy bodies dementia and others) could be classified. The main aim of the research was to establish a correlation between the clinical picture of the patient and the neuropathological post-mortem findings in the brain. A high prevalence of comorbidity of different pathologies was found. This questions the current traditional nosological classification, in which the predominant pathology is considered to be the most important and suggest a new multidimentional approach of dementia. In this new approach dementia is considered to be a syndrome constituted by a spectrum of symptoms and neuropathological findings.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Verhey, Frans, Supervisor
  • Uylings, H.B.M., Supervisor, External person
  • Burgmans, S., Co-Supervisor, External person
Award date18 Oct 2012
Place of PublicationMaastricht
Print ISBNs9789075579611
Publication statusPublished - 1 Jan 2012


  • Brain Bank
  • Alzheimer's disease
  • vascular dementia
  • neuropathology

Cite this