Multiparametric autoimmune diagnostics: recent advances

Jan Damoiseaux*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Autoimmune diagnostics in a routine clinical laboratory is constantly challenged by the discovery of new autoantibodies and technical innovations in the immunoassays applied. These challenges are, in particular, combined in the multiparametric immunoassays. Appropriate positioning of multiparametric immunoassays within the laboratory requires integrated knowledge of the clinical performance of the test system for each individual antigen, the conditions prescribed in disease criteria and/or guidelines, and the demands of the clinicians. This review provides a summary of the multiparametric immunoassays available, as well as the applications and restrictions in routine clinical practice.
Original languageEnglish
Pages (from-to)15-25
JournalPathology and Laboratory Medicine International
Publication statusPublished - 2016


  • autoantibodies
  • line immunoassay
  • dot immunoassay
  • addressable laser bead immunoassay
  • indirect immunofluorescence


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