Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Jorge Piano Simoes; Elza Daoud; Maryam Shabbir; Sana Amanat; Kelly Assouly; Roshni Biswas; Chiara Casolani; Albi Dode; Falco Enzler; Laure Jacquemin; Mie Joergensen; Tori Kok; Nuwan Liyanage; Matheus Lourenco; Punitkumar Makani; Muntazir Mehdi; Anissa L. Ramadhani; Constanze Riha; Jose Lopez Santacruz; Axel Schiller; Stefan Schoisswohl; Natalia Trpchevska; Eleni Genitsaridi

doi:10.3389/fnagi.2021.647285

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Jorge Piano Simoes^*, Elza Daoud^*, Maryam Shabbir^*, Sana Amanat, Kelly Assouly, Roshni Biswas, Chiara Casolani, Albi Dode, Falco Enzler, Laure Jacquemin, Mie Joergensen, Tori Kok, Nuwan Liyanage, Matheus Lourenco, Punitkumar Makani, Muntazir Mehdi, Anissa L. Ramadhani, Constanze Riha, Jose Lopez Santacruz, Axel SchillerStefan Schoisswohl, Natalia Trpchevska, Eleni Genitsaridi^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.

Original language	English
Article number	647285
Number of pages	24
Journal	Frontiers in Aging Neuroscience
Volume	13
DOIs	https://doi.org/10.3389/fnagi.2021.647285
Publication status	Published - 11 Jun 2021

Keywords

tinnitus
review
heterogeneity
standardization
interdisciplinary collaborations
big data
treatment development
TRANSCRANIAL MAGNETIC STIMULATION
GENOME-WIDE ASSOCIATION
STATE FUNCTIONAL CONNECTIVITY
RESIDUAL INHIBITION FUNCTIONS
AMPLITUDE-MODULATED SOUNDS
COGNITIVE-BEHAVIOR THERAPY
THETA BURST STIMULATION
HUMAN AUDITORY-CORTEX
QUALITY-OF-LIFE
SUBJECTIVE TINNITUS

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1 Erratum / corrigendum / retractions

Corrigendum: Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers
Simoes, J. P., Daoud, E., Shabbir, M., Amanat, S., Assouly, K., Biswas, R., Casolani, C., Dode, A., Enzler, F., Jacquemin, L., Joergensen, M., Kok, T., Liyanage, N., Lourenco, M., Makani, P., Mehdi, M., Ramadhani, A. L., Riha, C., Santacruz, J. L. & Schiller, A. & 3 others, Schoisswohl, S., Trpchevska, N. & Genitsaridi, E., 9 Aug 2021, In: Frontiers in Aging Neuroscience. 13, 2 p., 730758.
Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

Open Access

Cite this

Simoes, J. P., Daoud, E., Shabbir, M., Amanat, S., Assouly, K., Biswas, R., Casolani, C., Dode, A., Enzler, F., Jacquemin, L., Joergensen, M., Kok, T., Liyanage, N., Lourenco, M., Makani, P., Mehdi, M., Ramadhani, A. L., Riha, C., Santacruz, J. L., ... Genitsaridi, E. (2021). Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers. Frontiers in Aging Neuroscience, 13, Article 647285. https://doi.org/10.3389/fnagi.2021.647285

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title = "Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers",

abstract = "Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.",

keywords = "tinnitus, review, heterogeneity, standardization, interdisciplinary collaborations, big data, treatment development, TRANSCRANIAL MAGNETIC STIMULATION, GENOME-WIDE ASSOCIATION, STATE FUNCTIONAL CONNECTIVITY, RESIDUAL INHIBITION FUNCTIONS, AMPLITUDE-MODULATED SOUNDS, COGNITIVE-BEHAVIOR THERAPY, THETA BURST STIMULATION, HUMAN AUDITORY-CORTEX, QUALITY-OF-LIFE, SUBJECTIVE TINNITUS",

author = "Simoes, {Jorge Piano} and Elza Daoud and Maryam Shabbir and Sana Amanat and Kelly Assouly and Roshni Biswas and Chiara Casolani and Albi Dode and Falco Enzler and Laure Jacquemin and Mie Joergensen and Tori Kok and Nuwan Liyanage and Matheus Lourenco and Punitkumar Makani and Muntazir Mehdi and Ramadhani, {Anissa L.} and Constanze Riha and Santacruz, {Jose Lopez} and Axel Schiller and Stefan Schoisswohl and Natalia Trpchevska and Eleni Genitsaridi",

note = "Funding Information: Funding. This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements number 722046, 764604, and 848261. Funding Information: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements number 722046, 764604, and 848261. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Simoes, Daoud, Shabbir, Amanat, Assouly, Biswas, Casolani, Dode, Enzler, Jacquemin, Joergensen, Kok, Liyanage, Lourenco, Makani, Mehdi, Ramadhani, Riha, Santacruz, Schiller, Schoisswohl, Trpchevska and Genitsaridi.",

year = "2021",

month = jun,

day = "11",

doi = "10.3389/fnagi.2021.647285",

language = "English",

volume = "13",

journal = "Frontiers in Aging Neuroscience",

issn = "1663-4365",

publisher = "Frontiers Media S.A.",

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Simoes, JP, Daoud, E, Shabbir, M, Amanat, S, Assouly, K, Biswas, R, Casolani, C, Dode, A, Enzler, F, Jacquemin, L, Joergensen, M, Kok, T, Liyanage, N, Lourenco, M, Makani, P, Mehdi, M, Ramadhani, AL, Riha, C, Santacruz, JL, Schiller, A, Schoisswohl, S, Trpchevska, N & Genitsaridi, E 2021, 'Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers', Frontiers in Aging Neuroscience, vol. 13, 647285. https://doi.org/10.3389/fnagi.2021.647285

TY - JOUR

T1 - Multidisciplinary Tinnitus Research

T2 - Challenges and Future Directions From the Perspective of Early Stage Researchers

AU - Simoes, Jorge Piano

AU - Daoud, Elza

AU - Shabbir, Maryam

AU - Amanat, Sana

AU - Assouly, Kelly

AU - Biswas, Roshni

AU - Casolani, Chiara

AU - Dode, Albi

AU - Enzler, Falco

AU - Jacquemin, Laure

AU - Joergensen, Mie

AU - Kok, Tori

AU - Liyanage, Nuwan

AU - Lourenco, Matheus

AU - Makani, Punitkumar

AU - Mehdi, Muntazir

AU - Ramadhani, Anissa L.

AU - Riha, Constanze

AU - Santacruz, Jose Lopez

AU - Schiller, Axel

AU - Schoisswohl, Stefan

AU - Trpchevska, Natalia

AU - Genitsaridi, Eleni

N1 - Funding Information: Funding. This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements number 722046, 764604, and 848261. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements number 722046, 764604, and 848261. Publisher Copyright: © Copyright © 2021 Simoes, Daoud, Shabbir, Amanat, Assouly, Biswas, Casolani, Dode, Enzler, Jacquemin, Joergensen, Kok, Liyanage, Lourenco, Makani, Mehdi, Ramadhani, Riha, Santacruz, Schiller, Schoisswohl, Trpchevska and Genitsaridi.

PY - 2021/6/11

Y1 - 2021/6/11

N2 - Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.

AB - Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.

KW - tinnitus

KW - review

KW - heterogeneity

KW - standardization

KW - interdisciplinary collaborations

KW - big data

KW - treatment development

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - GENOME-WIDE ASSOCIATION

KW - STATE FUNCTIONAL CONNECTIVITY

KW - RESIDUAL INHIBITION FUNCTIONS

KW - AMPLITUDE-MODULATED SOUNDS

KW - COGNITIVE-BEHAVIOR THERAPY

KW - THETA BURST STIMULATION

KW - HUMAN AUDITORY-CORTEX

KW - QUALITY-OF-LIFE

KW - SUBJECTIVE TINNITUS

U2 - 10.3389/fnagi.2021.647285

DO - 10.3389/fnagi.2021.647285

M3 - (Systematic) Review article

C2 - 34177549

SN - 1663-4365

VL - 13

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

M1 - 647285

ER -

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Abstract

Keywords

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Research output

Corrigendum: Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Cite this