Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design

Vicky Chalos; Rob A. van de Graaf; Bob Roozenbeek; Adriaan C. G. M. van Es; Heleen M. den Hertog; Julie Staals; Lukas van Dijk; Sjoerd F. M. Jenniskens; Robert J. van Oostenbrugge; Wim H. van Zwam; Yvo B. W. E. M. Roos; Charles B. L. M. Majoie; Hester F. Lingsma; Aad van der Lugt; Diederik W. J. Dippel; MR CLEAN-MED investigators

doi:10.1186/s13063-020-04514-9

Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design

Vicky Chalos, Rob A. van de Graaf, Bob Roozenbeek^*, Adriaan C. G. M. van Es, Heleen M. den Hertog, Julie Staals, Lukas van Dijk, Sjoerd F. M. Jenniskens, Robert J. van Oostenbrugge, Wim H. van Zwam, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Hester F. Lingsma, Aad van der Lugt, Diederik W. J. Dippel, MR CLEAN-MED investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	644
Number of pages	17
Journal	Trials
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s13063-020-04514-9
Publication status	Published - 14 Jul 2020

Keywords

Ischemic stroke
Acetylsalicylic acid
Heparin
Cerebrovascular disorders
Randomized controlled trial
Endovascular treatment
Thrombectomy
Periprocedural
INFORMED-CONSENT PROCEDURE
FOCAL CEREBRAL-ISCHEMIA
INTRACRANIAL HEMORRHAGE
INTRAARTERIAL TREATMENT
DEFERRED CONSENT
NO-REFLOW
OCCLUSION
REPERFUSION
THERAPY
INJURY

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Chalos, V., van de Graaf, R. A., Roozenbeek, B., van Es, A. C. G. M., den Hertog, H. M., Staals, J., van Dijk, L., Jenniskens, S. F. M., van Oostenbrugge, R. J., van Zwam, W. H., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., & MR CLEAN-MED investigators (2020). Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design. Trials, 21(1), [644]. https://doi.org/10.1186/s13063-020-04514-9

Chalos, Vicky ; van de Graaf, Rob A. ; Roozenbeek, Bob ; van Es, Adriaan C. G. M. ; den Hertog, Heleen M. ; Staals, Julie ; van Dijk, Lukas ; Jenniskens, Sjoerd F. M. ; van Oostenbrugge, Robert J. ; van Zwam, Wim H. ; Roos, Yvo B. W. E. M. ; Majoie, Charles B. L. M. ; Lingsma, Hester F. ; van der Lugt, Aad ; Dippel, Diederik W. J. ; MR CLEAN-MED investigators. / Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication : acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design. In: Trials. 2020 ; Vol. 21, No. 1.

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title = "Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design",

keywords = "Ischemic stroke, Acetylsalicylic acid, Heparin, Cerebrovascular disorders, Randomized controlled trial, Endovascular treatment, Thrombectomy, Periprocedural, INFORMED-CONSENT PROCEDURE, FOCAL CEREBRAL-ISCHEMIA, INTRACRANIAL HEMORRHAGE, INTRAARTERIAL TREATMENT, DEFERRED CONSENT, NO-REFLOW, OCCLUSION, REPERFUSION, THERAPY, INJURY",

author = "Vicky Chalos and {van de Graaf}, {Rob A.} and Bob Roozenbeek and {van Es}, {Adriaan C. G. M.} and {den Hertog}, {Heleen M.} and Julie Staals and {van Dijk}, Lukas and Jenniskens, {Sjoerd F. M.} and {van Oostenbrugge}, {Robert J.} and {van Zwam}, {Wim H.} and Roos, {Yvo B. W. E. M.} and Majoie, {Charles B. L. M.} and Lingsma, {Hester F.} and {van der Lugt}, Aad and Dippel, {Diederik W. J.} and {MR CLEAN-MED investigators}",

year = "2020",

month = jul,

day = "14",

doi = "10.1186/s13063-020-04514-9",

language = "English",

volume = "21",

journal = "Trials",

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Chalos, V, van de Graaf, RA, Roozenbeek, B, van Es, ACGM, den Hertog, HM, Staals, J, van Dijk, L, Jenniskens, SFM, van Oostenbrugge, RJ , van Zwam, WH, Roos, YBWEM, Majoie, CBLM, Lingsma, HF, van der Lugt, A, Dippel, DWJ & MR CLEAN-MED investigators 2020, 'Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design', Trials, vol. 21, no. 1, 644. https://doi.org/10.1186/s13063-020-04514-9

Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication : acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design. / Chalos, Vicky; van de Graaf, Rob A.; Roozenbeek, Bob; van Es, Adriaan C. G. M.; den Hertog, Heleen M.; Staals, Julie; van Dijk, Lukas; Jenniskens, Sjoerd F. M.; van Oostenbrugge, Robert J.; van Zwam, Wim H.; Roos, Yvo B. W. E. M.; Majoie, Charles B. L. M.; Lingsma, Hester F.; van der Lugt, Aad; Dippel, Diederik W. J.; MR CLEAN-MED investigators.

In: Trials, Vol. 21, No. 1, 644, 14.07.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication

T2 - acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design

AU - Chalos, Vicky

AU - van de Graaf, Rob A.

AU - Roozenbeek, Bob

AU - van Es, Adriaan C. G. M.

AU - den Hertog, Heleen M.

AU - Staals, Julie

AU - van Dijk, Lukas

AU - Jenniskens, Sjoerd F. M.

AU - van Oostenbrugge, Robert J.

AU - van Zwam, Wim H.

AU - Roos, Yvo B. W. E. M.

AU - Majoie, Charles B. L. M.

AU - Lingsma, Hester F.

AU - van der Lugt, Aad

AU - Dippel, Diederik W. J.

AU - MR CLEAN-MED investigators

PY - 2020/7/14

Y1 - 2020/7/14

KW - Ischemic stroke

KW - Acetylsalicylic acid

KW - Heparin

KW - Cerebrovascular disorders

KW - Randomized controlled trial

KW - Endovascular treatment

KW - Thrombectomy

KW - Periprocedural

KW - INFORMED-CONSENT PROCEDURE

KW - FOCAL CEREBRAL-ISCHEMIA

KW - INTRACRANIAL HEMORRHAGE

KW - INTRAARTERIAL TREATMENT

KW - DEFERRED CONSENT

KW - NO-REFLOW

KW - OCCLUSION

KW - REPERFUSION

KW - THERAPY

KW - INJURY

U2 - 10.1186/s13063-020-04514-9

DO - 10.1186/s13063-020-04514-9

M3 - Article

C2 - 32665035

VL - 21

JO - Trials

JF - Trials

SN - 1745-6215

IS - 1

M1 - 644

ER -

Chalos V, van de Graaf RA, Roozenbeek B, van Es ACGM, den Hertog HM, Staals J et al. Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design. Trials. 2020 Jul 14;21(1). 644. https://doi.org/10.1186/s13063-020-04514-9