Multicenter Harmonization of Zr-89 PET/CT Performance

Nikolaos E. Makris*, Ronald Boellaard, Eric P. Visser, Johan R. de Jong, Bruno Vanderlinden, Roel Wierts, Berlinda J. van der Veen, Henri J. N. M. Greuter, Danielle J. Vugts, Guus A. M. S. van Dongen, Adriaan A. Lammertsma, Marc C. Huisman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Web of Science)


This study investigated the feasibility of quantitative accuracy and harmonized image quality in Zr-89-PET/CT multicenter studies. Methods: Five PET/CT scanners from 3 vendors were included. Zr-89 activity was measured in a central dose calibrator before delivery. Local activity assays were based on volume as well as on the local dose calibrator. Accuracy and image noise were determined from a cross calibration experiment. Image quality was assessed from recovery coefficients derived from different volume-of-interest (VOI) methods (VOIA50%, based on a 3-dimensional isocontour at 50% of the maximum voxel value with local background correction; VOImax, based on the voxel with the highest uptake; and VOI3Dpeak, based on a spheric VOI of 1.2-cm diameter positioned so as to maximize the enclosed average). PET images were analyzed before and after postreconstruction smoothing, applied to match image noise. Results: PET/CT accuracy and image noise ranged from -3% to 10% and from 13% to 22%, respectively. VOI3Dpeak produced the most reproducible recovery coefficients. After calibration of the local dose calibrator to the central dose calibrator, differences between the local activity assays were within 6%. Conclusion: This study showed that quantitative accuracy and harmonized image quality can be reached in Zr-89 PET/CT multicenter studies.
Original languageEnglish
Pages (from-to)264-267
JournalJournal of Nuclear Medicine
Issue number2
Publication statusPublished - Feb 2014


  • Zr-89-PET
  • multi-center
  • image quality
  • cross calibration
  • harmonization

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