Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD

Sarah Kittel-Schneider*, Martin Reuss, Andrea Meyer, Heike Weber, Alexandra Gessner, Carolin Leistner, Juliane Kopf, Brigitte Schmidt, Susanne Hempel, Julia Volkert, Klaus-Peter Lesch, Andreas Reif

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx (-)) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular.The concentrations of NO2 (-) and NO3 (-) in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene (NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed.We found significantly lower NOx (-) levels in BPD (p
Original languageEnglish
Pages (from-to)31-38
JournalJournal of Psychopharmacology
Issue number1
Publication statusPublished - Jan 2015


  • Nitric oxide
  • bipolar disorder
  • attention deficit-hyperactivity disorder
  • genetic polymorphism
  • biomarkers

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