Multi-channel amplitude-integrated EEG characteristics in preterm infants with a normal neurodevelopment at two years of corrected age

Hendrik J. Niemarkt, Ward Jennekens, Imke A. Maartens, Tessa Wassenberg, Marijke van Aken, Titia Katgert, Boris W. Kramer, Antonio W. D. Gavilanes, Luc J. Zimmermann, Sidarto Bambang Oetomo, Peter Andriessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Web of Science)


Aim: To analyze quantitatively multi-channel amplitude-integrated EEG (aEEG) characteristics and assess regional differences. Methods: We investigated 40 preterm infants (postmenstrual age, PMA: range 27-37 weeks) with normal follow-up at 24 months of age, at a median postnatal age of 8 days using 4-h EEG recordings according to the international 10-20 system reduced montage. Nine (3 transverse and 6 longitudinal) channels were selected and converted to aEEG registrations. For each aEEG registration, lower margin amplitude (LMA), upper margin amplitude (UMA) and bandwidth (UMA-LMA) were calculated. Results: In all channels PMA and LMA showed strong positive correlations. Below 32 weeks of PMA. LMA was 32 weeks) brain. Conclusions: We detected symmetric increase of aEEG characteristics, indicating symmetric brain maturation of the left and right hemispheres. Our findings demonstrate the clinical potential of computer-assisted analyses of aEEG recordings in detecting maturational features which are not readily identified visually. This may provide an objective and reproducible method for assessing brain maturation and long-term prognosis.
Original languageEnglish
Pages (from-to)209-216
JournalEarly Human Development
Issue number4
Publication statusPublished - Apr 2012


  • EEG
  • Amplitude-integrated EEG
  • Computer-assisted signal processing
  • Premature infant

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