MSP: an emerging player in metabolic syndrome

Jieyi Li, D. Chanda, Ronit Shiri-Sverdlov, D. Neumann

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

MSP (Macrophage Stimulating Protein; also known as Hepatocyte Growth Factor-like protein (HGFL) and MST1) is a secreted protein and the ligand for transmembrane receptor tyrosine kinase Recepteur d'Origine Nantais (RON; also known as MST1R). Since its discovery, MSP has been demonstrated to play a key role in regulating inflammation in the peripheral tissues of multiple disease models. Recent evidences also point toward a beneficial role of MSP in the regulation of hepatic lipid and glucose metabolism, thereby implicating MSP as a crucial regulator in maintaining metabolic homeostasis while simultaneously suppressing inflammatory processes. In this review, we discuss the recent advances that demonstrate the significance of MSP in metabolic syndrome and build a strong case supporting its therapeutic potential.
Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalCytokine & Growth Factor Reviews
Volume26
Issue number1
DOIs
Publication statusPublished - Feb 2015

Keywords

  • MSP
  • RON
  • Inflammation
  • Metabolic syndrome
  • MACROPHAGE-STIMULATING PROTEIN
  • HEPATOCYTE-GROWTH-FACTOR
  • RECEPTOR TYROSINE KINASE
  • MURINE PERITONEAL-MACROPHAGES
  • INDUCED FATTY LIVER
  • INDUCED ACUTE LUNG
  • BETA-CELLS LEADS
  • RON RECEPTOR
  • C-MET
  • IFN-GAMMA

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