Abstract
MSP (Macrophage Stimulating Protein; also known as Hepatocyte Growth Factor-like protein (HGFL) and MST1) is a secreted protein and the ligand for transmembrane receptor tyrosine kinase Recepteur d'Origine Nantais (RON; also known as MST1R). Since its discovery, MSP has been demonstrated to play a key role in regulating inflammation in the peripheral tissues of multiple disease models. Recent evidences also point toward a beneficial role of MSP in the regulation of hepatic lipid and glucose metabolism, thereby implicating MSP as a crucial regulator in maintaining metabolic homeostasis while simultaneously suppressing inflammatory processes. In this review, we discuss the recent advances that demonstrate the significance of MSP in metabolic syndrome and build a strong case supporting its therapeutic potential.
Original language | English |
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Pages (from-to) | 75-82 |
Number of pages | 8 |
Journal | Cytokine & Growth Factor Reviews |
Volume | 26 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2015 |
Keywords
- MSP
- RON
- Inflammation
- Metabolic syndrome
- MACROPHAGE-STIMULATING PROTEIN
- HEPATOCYTE-GROWTH-FACTOR
- RECEPTOR TYROSINE KINASE
- MURINE PERITONEAL-MACROPHAGES
- INDUCED FATTY LIVER
- INDUCED ACUTE LUNG
- BETA-CELLS LEADS
- RON RECEPTOR
- C-MET
- IFN-GAMMA