MRI of Arterial Flow Reserve in Patients with Intermittent Claudication: Feasibility and Initial Experience

Bas Versluis; Marjolein H. G. Dremmen; Patty J. Nelemans; Joachim E. Wildberger; Geert-Willem Schurink; Tim Leiner; Walter H. Backes

doi:10.1371/journal.pone.0031514

MRI of Arterial Flow Reserve in Patients with Intermittent Claudication: Feasibility and Initial Experience

Bas Versluis^*, Marjolein H. G. Dremmen, Patty J. Nelemans, Joachim E. Wildberger, Geert-Willem Schurink, Tim Leiner, Walter H. Backes

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives: The aim of this work was to develop a MRI method to determine arterial flow reserve in patients with intermittent claudication and to investigate whether this method can discriminate between patients and healthy control subjects. Methods: Ten consecutive patients with intermittent claudication and 10 healthy control subjects were included. All subjects underwent vector cardiography triggered quantitative 2D cine MR phase-contrast imaging to obtain flow waveforms of the popliteal artery at rest and during reactive hyperemia. Resting flow, maximum hyperemic flow and absolute flow reserve were determined and compared between the two groups by two independent MRI readers. Also, interreader reproducibility of flow measures was reported. Results: Resting flow was lower in patients compared to controls (4.9 +/- 1.6 and 11.1 +/- 3.2 mL/s in patients and controls, respectively (p

Original language	English
Article number	e31514
Journal	PLOS ONE
Volume	7
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0031514
Publication status	Published - 8 Mar 2012

Access to Document

10.1371/journal.pone.0031514Licence: CC BY

Cite this

@article{1764b0ff8b094775947960c321bbcb65,

title = "MRI of Arterial Flow Reserve in Patients with Intermittent Claudication: Feasibility and Initial Experience",

abstract = "Objectives: The aim of this work was to develop a MRI method to determine arterial flow reserve in patients with intermittent claudication and to investigate whether this method can discriminate between patients and healthy control subjects. Methods: Ten consecutive patients with intermittent claudication and 10 healthy control subjects were included. All subjects underwent vector cardiography triggered quantitative 2D cine MR phase-contrast imaging to obtain flow waveforms of the popliteal artery at rest and during reactive hyperemia. Resting flow, maximum hyperemic flow and absolute flow reserve were determined and compared between the two groups by two independent MRI readers. Also, interreader reproducibility of flow measures was reported. Results: Resting flow was lower in patients compared to controls (4.9 +/- 1.6 and 11.1 +/- 3.2 mL/s in patients and controls, respectively (p",

author = "Bas Versluis and Dremmen, {Marjolein H. G.} and Nelemans, {Patty J.} and Wildberger, {Joachim E.} and Geert-Willem Schurink and Tim Leiner and Backes, {Walter H.}",

year = "2012",

month = mar,

day = "8",

doi = "10.1371/journal.pone.0031514",

language = "English",

volume = "7",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "3",

}

TY - JOUR

T1 - MRI of Arterial Flow Reserve in Patients with Intermittent Claudication: Feasibility and Initial Experience

AU - Versluis, Bas

AU - Dremmen, Marjolein H. G.

AU - Nelemans, Patty J.

AU - Wildberger, Joachim E.

AU - Schurink, Geert-Willem

AU - Leiner, Tim

AU - Backes, Walter H.

PY - 2012/3/8

Y1 - 2012/3/8

N2 - Objectives: The aim of this work was to develop a MRI method to determine arterial flow reserve in patients with intermittent claudication and to investigate whether this method can discriminate between patients and healthy control subjects. Methods: Ten consecutive patients with intermittent claudication and 10 healthy control subjects were included. All subjects underwent vector cardiography triggered quantitative 2D cine MR phase-contrast imaging to obtain flow waveforms of the popliteal artery at rest and during reactive hyperemia. Resting flow, maximum hyperemic flow and absolute flow reserve were determined and compared between the two groups by two independent MRI readers. Also, interreader reproducibility of flow measures was reported. Results: Resting flow was lower in patients compared to controls (4.9 +/- 1.6 and 11.1 +/- 3.2 mL/s in patients and controls, respectively (p

AB - Objectives: The aim of this work was to develop a MRI method to determine arterial flow reserve in patients with intermittent claudication and to investigate whether this method can discriminate between patients and healthy control subjects. Methods: Ten consecutive patients with intermittent claudication and 10 healthy control subjects were included. All subjects underwent vector cardiography triggered quantitative 2D cine MR phase-contrast imaging to obtain flow waveforms of the popliteal artery at rest and during reactive hyperemia. Resting flow, maximum hyperemic flow and absolute flow reserve were determined and compared between the two groups by two independent MRI readers. Also, interreader reproducibility of flow measures was reported. Results: Resting flow was lower in patients compared to controls (4.9 +/- 1.6 and 11.1 +/- 3.2 mL/s in patients and controls, respectively (p

U2 - 10.1371/journal.pone.0031514

DO - 10.1371/journal.pone.0031514

M3 - Article

C2 - 22412836

SN - 1932-6203

VL - 7

JO - PLOS ONE

JF - PLOS ONE

IS - 3

M1 - e31514

ER -