MR-guided breast biopsy at 3T: diagnostic yield of large core needle biopsy compared with vacuum-assisted biopsy

Carla Meeuwis*, Jeroen Veltman, Hester N. van Hall, Roel D. M. Mus, Carla Boetes, Jelle O. Barentsz, Ritse M. Mann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective The purpose of this study was to evaluate two MR-guided biopsy techniques at 3 T, large core needle breast biopsy (LCNB) and vacuum-assisted breast biopsy (VAB) and to compare the diagnostic yield and rate of complications to determine the optimal biopsy technique at 3 T. Methods 55 LCNB and 64 VAB were consecutively performed. Benign biopsy results were verified by retrospective correlation of histology, with pre-interventional, post-interventional MRI studies and follow-up and were classified as representative or non-representative. Time to follow-up was up to 2 years for the considered non-representative benign lesions. Statistical analysis was performed using the Chi-squared test. Results LCNB was technically successful in 100% of patients (55/55) and VAB in 98% of patients (63/64). Histopathological analysis resulted in 45 (82%) benign, 3 (5%) high-risk and 7 (13%) malignant lesions for LCNB and 43 (67%) benign, 3 (5%) high-risk and 18 (28%) malignant lesions. Distribution was significantly different (p <0.001), favouring VAB over LCNB. Conclusion Because of the substantially higher diagnostic yield and certainty of a benign diagnosis, VAB is the optimal biopsy technique at 3 T. LCNB should be considered when VAB is not feasible.
Original languageEnglish
Pages (from-to)341-349
JournalEuropean Radiology
Issue number2
Publication statusPublished - Feb 2012


  • Breast cancer
  • Biopsy
  • MRI
  • High field
  • Neoplasms

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