Motor nerve decline does not underlie muscle weakness in type 2 Diabetic neuropathy

T.H. Ijzerman*, N.C. Schaper, T. Melai, P. Blijham, K. Meijer, P.J. Willems, H.H. Savelberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Downloads (Pure)


Introduction: Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN. Methods: Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint. Results: The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength. Conclusion: These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function. Muscle Nerve, 2011.
Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalMuscle & Nerve
Issue number2
Publication statusPublished - 1 Jan 2011


Dive into the research topics of 'Motor nerve decline does not underlie muscle weakness in type 2 Diabetic neuropathy'. Together they form a unique fingerprint.

Cite this