Motor nerve decline does not underlie muscle weakness in type 2 Diabetic neuropathy

T.H. Ijzerman; N.C. Schaper; T. Melai; P. Blijham; K. Meijer; P.J. Willems; H.H. Savelberg

doi:10.1002/mus.22039

Motor nerve decline does not underlie muscle weakness in type 2 Diabetic neuropathy

T.H. Ijzerman^*, N.C. Schaper, T. Melai, P. Blijham, K. Meijer, P.J. Willems, H.H. Savelberg

^*Corresponding author for this work

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Abstract

Introduction: Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN. Methods: Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint. Results: The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength. Conclusion: These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function. Muscle Nerve, 2011.

Original language	English
Pages (from-to)	241-245
Number of pages	5
Journal	Muscle & Nerve
Volume	44
Issue number	2
DOIs	https://doi.org/10.1002/mus.22039
Publication status	Published - 1 Jan 2011

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title = "Motor nerve decline does not underlie muscle weakness in type 2 Diabetic neuropathy",

abstract = "Introduction: Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN. Methods: Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint. Results: The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength. Conclusion: These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function. Muscle Nerve, 2011.",

author = "T.H. Ijzerman and N.C. Schaper and T. Melai and P. Blijham and K. Meijer and P.J. Willems and H.H. Savelberg",

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T1 - Motor nerve decline does not underlie muscle weakness in type 2 Diabetic neuropathy

AU - Ijzerman, T.H.

AU - Schaper, N.C.

AU - Melai, T.

AU - Blijham, P.

AU - Meijer, K.

AU - Willems, P.J.

AU - Savelberg, H.H.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Introduction: Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN. Methods: Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint. Results: The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength. Conclusion: These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function. Muscle Nerve, 2011.

AB - Introduction: Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN. Methods: Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint. Results: The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength. Conclusion: These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function. Muscle Nerve, 2011.

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DO - 10.1002/mus.22039

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