Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease

Y. Temel; C. Cao; R. Vlamings; A. Blokland; H. Ozen; H.W. Steinbusch; K.A. Michelsen; S. von Horsten; C. Schmitz; V. Vandewalle

doi:10.1016/j.neulet.2006.07.036

Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease

Y. Temel^*, C. Cao, R. Vlamings, A. Blokland, H. Ozen, H.W. Steinbusch, K.A. Michelsen, S. von Horsten, C. Schmitz, V. Vandewalle

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.

Original language	English
Pages (from-to)	138-141
Journal	Neuroscience Letters
Volume	406
DOIs	https://doi.org/10.1016/j.neulet.2006.07.036
Publication status	Published - 1 Jan 2006

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10.1016/j.neulet.2006.07.036

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title = "Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease",

abstract = "Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD. ",

author = "Y. Temel and C. Cao and R. Vlamings and A. Blokland and H. Ozen and H.W. Steinbusch and K.A. Michelsen and {von Horsten}, S. and C. Schmitz and V. Vandewalle",

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doi = "10.1016/j.neulet.2006.07.036",

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T1 - Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease

AU - Temel, Y.

AU - Cao, C.

AU - Vlamings, R.

AU - Blokland, A.

AU - Ozen, H.

AU - Steinbusch, H.W.

AU - Michelsen, K.A.

AU - von Horsten, S.

AU - Schmitz, C.

AU - Vandewalle, V.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.

AB - Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.

U2 - 10.1016/j.neulet.2006.07.036

DO - 10.1016/j.neulet.2006.07.036

M3 - Article

C2 - 16905252

SN - 0304-3940

VL - 406

SP - 138

EP - 141

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease

Abstract

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