Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging

K. Scupakova, F. Dewez, A.K. Walch, R.M.A. Heeren*, B. Balluff

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)

Abstract

The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
Original languageEnglish
Pages (from-to)17447-17450
Number of pages4
JournalAngewandte Chemie-International Edition
Volume59
Issue number40
DOIs
Publication statusPublished - 28 Sep 2020

Keywords

  • imaging
  • lipids
  • mass spectrometry
  • morphometry
  • single-cell analysis

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