Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders.

T. Klaassen; W.J. Riedel; A. van Someren; N.E.P. Deutz; A. Honig; H.M. van Praag

doi:10.1016/S0006-3223(99)00082-7

Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders.

T. Klaassen, W.J. Riedel^*, A. van Someren, N.E.P. Deutz, A. Honig, H.M. van Praag

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

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Abstract

Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.

BACKGROUND: Acute tryptophan (TRP) depletion was evaluated in healthy volunteers with or without a family history of major affective disorder (FH+ versus FH-). METHODS: Twenty-seven subjects (16 FH+, 11 FH-) received 100 g of an amino acid mixture with and without TRP according to a placebo-controlled, double-blind cross-over design and a diet devoid of TRP for the next 24 hours. RESULTS: The ratio TRP/large neutral amino acids declined to 22% of baseline values after 6 hours, and increased during the night reaching 85% of baseline after 24 hours. Overall, after 6 hours, TRP depletion lead to a lowering of mood, but after 24 hours, these changes were no longer detected. Mood changes and gastrointestinal side effects were significantly more evident in FH+ subjects than in FH- subjects. CONCLUSIONS: Our data support the hypothesis that subjects with a positive family history for depression are predisposed to increased vulnerability to the adverse consequences of serotonergic imbalance.

Publication Types:
Clinical Trial
Controlled Clinical Trial

Original language	English
Pages (from-to)	489-497
Number of pages	9
Journal	Biological Psychiatry
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/S0006-3223(99)00082-7
Publication status	Published - 1 Jan 1999

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10.1016/S0006-3223(99)00082-7

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title = "Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders.",

abstract = "Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.BACKGROUND: Acute tryptophan (TRP) depletion was evaluated in healthy volunteers with or without a family history of major affective disorder (FH+ versus FH-). METHODS: Twenty-seven subjects (16 FH+, 11 FH-) received 100 g of an amino acid mixture with and without TRP according to a placebo-controlled, double-blind cross-over design and a diet devoid of TRP for the next 24 hours. RESULTS: The ratio TRP/large neutral amino acids declined to 22% of baseline values after 6 hours, and increased during the night reaching 85% of baseline after 24 hours. Overall, after 6 hours, TRP depletion lead to a lowering of mood, but after 24 hours, these changes were no longer detected. Mood changes and gastrointestinal side effects were significantly more evident in FH+ subjects than in FH- subjects. CONCLUSIONS: Our data support the hypothesis that subjects with a positive family history for depression are predisposed to increased vulnerability to the adverse consequences of serotonergic imbalance.Publication Types: Clinical Trial Controlled Clinical Trial",

author = "T. Klaassen and W.J. Riedel and {van Someren}, A. and N.E.P. Deutz and A. Honig and {van Praag}, H.M.",

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T1 - Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders.

AU - Klaassen, T.

AU - Riedel, W.J.

AU - van Someren, A.

AU - Deutz, N.E.P.

AU - Honig, A.

AU - van Praag, H.M.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.BACKGROUND: Acute tryptophan (TRP) depletion was evaluated in healthy volunteers with or without a family history of major affective disorder (FH+ versus FH-). METHODS: Twenty-seven subjects (16 FH+, 11 FH-) received 100 g of an amino acid mixture with and without TRP according to a placebo-controlled, double-blind cross-over design and a diet devoid of TRP for the next 24 hours. RESULTS: The ratio TRP/large neutral amino acids declined to 22% of baseline values after 6 hours, and increased during the night reaching 85% of baseline after 24 hours. Overall, after 6 hours, TRP depletion lead to a lowering of mood, but after 24 hours, these changes were no longer detected. Mood changes and gastrointestinal side effects were significantly more evident in FH+ subjects than in FH- subjects. CONCLUSIONS: Our data support the hypothesis that subjects with a positive family history for depression are predisposed to increased vulnerability to the adverse consequences of serotonergic imbalance.Publication Types: Clinical Trial Controlled Clinical Trial

AB - Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.BACKGROUND: Acute tryptophan (TRP) depletion was evaluated in healthy volunteers with or without a family history of major affective disorder (FH+ versus FH-). METHODS: Twenty-seven subjects (16 FH+, 11 FH-) received 100 g of an amino acid mixture with and without TRP according to a placebo-controlled, double-blind cross-over design and a diet devoid of TRP for the next 24 hours. RESULTS: The ratio TRP/large neutral amino acids declined to 22% of baseline values after 6 hours, and increased during the night reaching 85% of baseline after 24 hours. Overall, after 6 hours, TRP depletion lead to a lowering of mood, but after 24 hours, these changes were no longer detected. Mood changes and gastrointestinal side effects were significantly more evident in FH+ subjects than in FH- subjects. CONCLUSIONS: Our data support the hypothesis that subjects with a positive family history for depression are predisposed to increased vulnerability to the adverse consequences of serotonergic imbalance.Publication Types: Clinical Trial Controlled Clinical Trial

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