Mononuclear phagocytes in head and neck squamous cell carcinoma

Kenneth Wilfried Kross*, John Helge Heimdal, Hans Jorgen Aarstad

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)

Abstract

The head and neck squamous cell carcinoma microenvironments contain many immune cells and their secretory products. Many of these cells belong to the mononuclear phagocyte system. The aim of this review is to study the interactions between mononuclear phagocytes and head and neck squamous cell carcinoma tissue. The role of inflammation in tumours and the cytokine interleukin-6 will be highlighted. Future therapy strategies in the treatment of head and neck cancer might be directed towards mononuclear phagocytes and their cytokine production.
Original languageEnglish
Pages (from-to)335-344
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume267
Issue number3
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Mononuclear phagocytes
  • Innate immune system
  • Macrophages
  • Monocytes
  • Interleukin-6
  • Fragment spheroids
  • Head and neck squamous cell carcinoma

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