Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

R. Munuswamy; J. De Brandt; C. Burtin; W. Derave; J. Aumann; M.A. Spruit; L. Michiels

doi:10.2147/JIR.S320659

Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

R. Munuswamy
, J. De Brandt
, C. Burtin
, W. Derave
, J. Aumann
, M.A. Spruit
, L. Michiels^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.

Original language	English
Pages (from-to)	4503-4507
Number of pages	5
Journal	Journal of Inflammation Research
Volume	14
DOIs	https://doi.org/10.2147/JIR.S320659
Publication status	Published - 2021

Keywords

COPD
low-grade systemic inflammation
pCRP
mCRP

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title = "Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons",

abstract = "Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.",

keywords = "COPD, low-grade systemic inflammation, pCRP, mCRP",

author = "R. Munuswamy and \{De Brandt\}, J. and C. Burtin and W. Derave and J. Aumann and M.A. Spruit and L. Michiels",

year = "2021",

doi = "10.2147/JIR.S320659",

language = "English",

volume = "14",

pages = "4503--4507",

journal = "Journal of Inflammation Research",

issn = "1178-7031",

publisher = "Dove Medical Press Ltd.",

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TY - JOUR

T1 - Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

AU - Munuswamy, R.

AU - De Brandt, J.

AU - Burtin, C.

AU - Derave, W.

AU - Aumann, J.

AU - Spruit, M.A.

AU - Michiels, L.

PY - 2021

Y1 - 2021

N2 - Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.

AB - Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.

KW - COPD

KW - low-grade systemic inflammation

KW - pCRP

KW - mCRP

U2 - 10.2147/JIR.S320659

DO - 10.2147/JIR.S320659

M3 - Comment/Letter to the editor

C2 - 34522118

SN - 1178-7031

VL - 14

SP - 4503

EP - 4507

JO - Journal of Inflammation Research

JF - Journal of Inflammation Research

ER -

Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Abstract

Keywords

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