Abstract
BACKGROUND: Using benzodiazepines (BZDs) or Z-drugs in poly-therapy is a critical issue.OBJECTIVE: Identifying factors influencing the use of BZDs/Z-drugs in poly- vs mono-therapy in patients with or without substance use disorders (SUDs).METHODS: 986 inpatients were analysed. Socio-demographic and clinical variables were collected. BZD/Z-drug doses were compared via the Defined Daily Dose (DDD) and standardized as diazepam dose equivalents. Mann-Whitney, Chi-square, Fisher test, hierarchical multivariate regression analyses were run referring to the whole sample and to subjects with current SUDs, lifetime SUDs, current and lifetime SUDs, non-SUDs.RESULTS: In the whole sample the variance of being mono- vs poly-therapy users was explained by BZD/Z-drug formulation, DDD, duration of treatment, age of first BZDs/Z-drugs use (Delta R-2 = 0.141, p < 0.001). Among those with current SUDs (Delta R-2 = 0.278, p = 0.332) or current and lifetime SUDs (Delta R-2 = 0.154, p = 0.419), no variables explained the variance of being mono-vs poly-therapy users. Among lifetime SUDs subjects, the variance of being mono- vs poly-therapy users was explained by BZD/Z-drug formulation and age of first BZD/Z-drug use (Delta R-2 = 0.275, p < 0.001). Among non-SUDs subjects, the variance of being mono- vs poly-therapy users was explained by DDD and duration of treatment (Delta R-2 = 0.162, p = 0.001).CONCLUSIONS: Tablets, high drug doses, long duration of treatment, and early age of first use were more likely associated to poly- than mono-therapy. This suggests that patients have different clinical features and a pharmacological prescription should be tailored to them also based on the variables here analysed.
Original language | English |
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Pages (from-to) | 295-320 |
Number of pages | 26 |
Journal | International Journal of Risk and Safety in Medicine |
Volume | 32 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Mono-therapy
- poly-therapy
- poly-pharmacy
- substance use disorder
- benzodiazepine
- Z-drug
- LONG-TERM USE
- ADULT-POPULATION
- LORMETAZEPAM
- PREVALENCE
- HYPNOTICS
- MISUSE