Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium

G.D. von Gersdorff; L. Usvyat; D. Marcelli; A. Grassmann; C. Marelli; M. Etter; J.P. Kooman; A. Power; T. Toffelmire; Y. S. Haviv; A. Guinsburg; C. Barth; M. Schaller; I. Bayh; L. Scatizzi; A. Tashman; S. Thijssen; N.W. Levin; F.M. van der Sande; C. Pusey; Y. Wang; P. Kotanko

doi:10.1159/000356088

Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium

G.D. von Gersdorff, L. Usvyat, D. Marcelli, A. Grassmann, C. Marelli, M. Etter, J.P. Kooman, A. Power, T. Toffelmire, Y. S. Haviv, A. Guinsburg, C. Barth, M. Schaller, I. Bayh, L. Scatizzi, A. Tashman, S. Thijssen, N.W. Levin, F.M. van der Sande, C. PuseyY. Wang, P. Kotanko^*

^*Corresponding author for this work

Interne Geneeskunde

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background/Aims: Dialysis providers frequently collect detailed longitudinal and standardized patient data, providing valuable registries of routine care. However, even large organizations are restricted to certain regions, limiting their ability to separate effects of local practice from the pathophysiology shared by most dialysis patients. To overcome this limitation, the MONDO (MONitoring Dialysis Outcomes) research consortium has created a platform for the joint analysis of data from almost 200,000 dialysis patients worldwide. Methods: We examined design and operation of MONDO as well as its methodology with respect to patient inclusion, descriptive data and other study parameters. Results: MONDO partners contribute primary databases of anonymized patient data and collaboratively analyze populations across national and regional boundaries. To that end, datasets from different electronic health record systems are converted into a uniform structure. Patients are enrolled without systematic exclusions into open cohorts representing the diversity of patients. A large number of patient level treatment and outcome data is recorded frequently and can be analyzed with little delay. Detailed variable definitions are used to determine if a parameter can be studied in a subset or all databases. Conclusion: MONDO has created a large repository of validated dialysis data, expanding the opportunities for outcome studies in dialysis patients. The density of longitudinal information facilitates in particular trend analysis. Limitations include the paucity of uniform definitions and standards regarding descriptive information (e.g. comorbidities), which limits the identification of patient subsets. Through its global outreach, depth, breadth and size, MONDO advances the observational study of dialysis patients and care. (c) 2013 S. Karger AG, Basel.

Original language	English
Pages (from-to)	165-172
Journal	Blood Purification
Volume	36
Issue number	3-4
DOIs	https://doi.org/10.1159/000356088
Publication status	Published - 1 Jan 2013

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10.1159/000356088

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von Gersdorff, G. D., Usvyat, L., Marcelli, D., Grassmann, A., Marelli, C., Etter, M., Kooman, J. P., Power, A., Toffelmire, T., Haviv, Y. S., Guinsburg, A., Barth, C., Schaller, M., Bayh, I., Scatizzi, L., Tashman, A., Thijssen, S., Levin, N. W., van der Sande, F. M., ... Kotanko, P. (2013). Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium. Blood Purification, 36(3-4), 165-172. https://doi.org/10.1159/000356088

@article{37219932e4a9460ea8958fc84a253987,

title = "Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium",

abstract = "Background/Aims: Dialysis providers frequently collect detailed longitudinal and standardized patient data, providing valuable registries of routine care. However, even large organizations are restricted to certain regions, limiting their ability to separate effects of local practice from the pathophysiology shared by most dialysis patients. To overcome this limitation, the MONDO (MONitoring Dialysis Outcomes) research consortium has created a platform for the joint analysis of data from almost 200,000 dialysis patients worldwide. Methods: We examined design and operation of MONDO as well as its methodology with respect to patient inclusion, descriptive data and other study parameters. Results: MONDO partners contribute primary databases of anonymized patient data and collaboratively analyze populations across national and regional boundaries. To that end, datasets from different electronic health record systems are converted into a uniform structure. Patients are enrolled without systematic exclusions into open cohorts representing the diversity of patients. A large number of patient level treatment and outcome data is recorded frequently and can be analyzed with little delay. Detailed variable definitions are used to determine if a parameter can be studied in a subset or all databases. Conclusion: MONDO has created a large repository of validated dialysis data, expanding the opportunities for outcome studies in dialysis patients. The density of longitudinal information facilitates in particular trend analysis. Limitations include the paucity of uniform definitions and standards regarding descriptive information (e.g. comorbidities), which limits the identification of patient subsets. Through its global outreach, depth, breadth and size, MONDO advances the observational study of dialysis patients and care. (c) 2013 S. Karger AG, Basel.",

author = "{von Gersdorff}, G.D. and L. Usvyat and D. Marcelli and A. Grassmann and C. Marelli and M. Etter and J.P. Kooman and A. Power and T. Toffelmire and Haviv, {Y. S.} and A. Guinsburg and C. Barth and M. Schaller and I. Bayh and L. Scatizzi and A. Tashman and S. Thijssen and N.W. Levin and {van der Sande}, F.M. and C. Pusey and Y. Wang and P. Kotanko",

year = "2013",

month = jan,

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doi = "10.1159/000356088",

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von Gersdorff, GD, Usvyat, L, Marcelli, D, Grassmann, A, Marelli, C, Etter, M, Kooman, JP, Power, A, Toffelmire, T, Haviv, YS, Guinsburg, A, Barth, C, Schaller, M, Bayh, I, Scatizzi, L, Tashman, A, Thijssen, S, Levin, NW, van der Sande, FM, Pusey, C, Wang, Y & Kotanko, P 2013, 'Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium', Blood Purification, vol. 36, no. 3-4, pp. 165-172. https://doi.org/10.1159/000356088

TY - JOUR

T1 - Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium

AU - von Gersdorff, G.D.

AU - Usvyat, L.

AU - Marcelli, D.

AU - Grassmann, A.

AU - Marelli, C.

AU - Etter, M.

AU - Kooman, J.P.

AU - Power, A.

AU - Toffelmire, T.

AU - Haviv, Y. S.

AU - Guinsburg, A.

AU - Barth, C.

AU - Schaller, M.

AU - Bayh, I.

AU - Scatizzi, L.

AU - Tashman, A.

AU - Thijssen, S.

AU - Levin, N.W.

AU - van der Sande, F.M.

AU - Pusey, C.

AU - Wang, Y.

AU - Kotanko, P.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background/Aims: Dialysis providers frequently collect detailed longitudinal and standardized patient data, providing valuable registries of routine care. However, even large organizations are restricted to certain regions, limiting their ability to separate effects of local practice from the pathophysiology shared by most dialysis patients. To overcome this limitation, the MONDO (MONitoring Dialysis Outcomes) research consortium has created a platform for the joint analysis of data from almost 200,000 dialysis patients worldwide. Methods: We examined design and operation of MONDO as well as its methodology with respect to patient inclusion, descriptive data and other study parameters. Results: MONDO partners contribute primary databases of anonymized patient data and collaboratively analyze populations across national and regional boundaries. To that end, datasets from different electronic health record systems are converted into a uniform structure. Patients are enrolled without systematic exclusions into open cohorts representing the diversity of patients. A large number of patient level treatment and outcome data is recorded frequently and can be analyzed with little delay. Detailed variable definitions are used to determine if a parameter can be studied in a subset or all databases. Conclusion: MONDO has created a large repository of validated dialysis data, expanding the opportunities for outcome studies in dialysis patients. The density of longitudinal information facilitates in particular trend analysis. Limitations include the paucity of uniform definitions and standards regarding descriptive information (e.g. comorbidities), which limits the identification of patient subsets. Through its global outreach, depth, breadth and size, MONDO advances the observational study of dialysis patients and care. (c) 2013 S. Karger AG, Basel.

AB - Background/Aims: Dialysis providers frequently collect detailed longitudinal and standardized patient data, providing valuable registries of routine care. However, even large organizations are restricted to certain regions, limiting their ability to separate effects of local practice from the pathophysiology shared by most dialysis patients. To overcome this limitation, the MONDO (MONitoring Dialysis Outcomes) research consortium has created a platform for the joint analysis of data from almost 200,000 dialysis patients worldwide. Methods: We examined design and operation of MONDO as well as its methodology with respect to patient inclusion, descriptive data and other study parameters. Results: MONDO partners contribute primary databases of anonymized patient data and collaboratively analyze populations across national and regional boundaries. To that end, datasets from different electronic health record systems are converted into a uniform structure. Patients are enrolled without systematic exclusions into open cohorts representing the diversity of patients. A large number of patient level treatment and outcome data is recorded frequently and can be analyzed with little delay. Detailed variable definitions are used to determine if a parameter can be studied in a subset or all databases. Conclusion: MONDO has created a large repository of validated dialysis data, expanding the opportunities for outcome studies in dialysis patients. The density of longitudinal information facilitates in particular trend analysis. Limitations include the paucity of uniform definitions and standards regarding descriptive information (e.g. comorbidities), which limits the identification of patient subsets. Through its global outreach, depth, breadth and size, MONDO advances the observational study of dialysis patients and care. (c) 2013 S. Karger AG, Basel.

U2 - 10.1159/000356088

DO - 10.1159/000356088

M3 - Article

C2 - 24496186

SN - 0253-5068

VL - 36

SP - 165

EP - 172

JO - Blood Purification

JF - Blood Purification

IS - 3-4

ER -