Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas

Noah c. Helderman; Anne Sophie Van Der Werf-’T Lam; Diantha Terlouw; Sanne W. Bajwa-ten Broeke; Mar Rodríguez-Girondo; Demi van Egmond; Alexandra M.J. Langers; Monique E. van Leerdam; Emily Rayner; Christi J. van Asperen; Liselotte P. van Hest; Hans J.P. Gille; Floor A.M. Duijkers; Anja Wagner; Ellis L. Eikenboom; Tom G.W. Letteboer; Mirjam M. de Jong; Fonnet E. Bleeker; Encarna B. Gomez Garcìa; Manon Suerink; Carli M. Tops; Niels de Wind; Hans Morreau; Arnoud Boot; Tom Van Wezel; Maartje Nielsen; MSH6 TUMOR GROUP

doi:10.1053/j.gastro.2023.03.198

Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas

Noah c. Helderman
, Anne Sophie Van Der Werf-’T Lam
, Diantha Terlouw
, Sanne W. Bajwa-ten Broeke
, Mar Rodríguez-Girondo
, Demi van Egmond
, Alexandra M.J. Langers
, Monique E. van Leerdam
, Emily Rayner
, Christi J. van Asperen
, Liselotte P. van Hest
, Hans J.P. Gille
, Floor A.M. Duijkers
, Anja Wagner
, Ellis L. Eikenboom
, Tom G.W. Letteboer
, Mirjam M. de Jong
, Fonnet E. Bleeker
, Encarna B. Gomez Garcìa
, Manon Suerink

Carli M. Tops, Niels de Wind, Hans Morreau, Arnoud Boot, Tom Van Wezel, Maartje Nielsen^*, MSH6 TUMOR GROUP

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	271-274.e2
Number of pages	6
Journal	Gastroenterology
Volume	165
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2023.03.198
Publication status	Published - 1 Jul 2023

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10.1053/j.gastro.2023.03.198Licence: CC BY

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Helderman, N. C., Van Der Werf-’T Lam, A. S., Terlouw, D., Bajwa-ten Broeke, S. W., Rodríguez-Girondo, M., van Egmond, D., Langers, A. M. J., van Leerdam, M. E., Rayner, E., van Asperen, C. J., van Hest, L. P., Gille, H. J. P., Duijkers, F. A. M., Wagner, A., Eikenboom, E. L., Letteboer, T. G. W., de Jong, M. M., Bleeker, F. E., Gomez Garcìa, E. B., ... MSH6 TUMOR GROUP (2023). Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas. Gastroenterology, 165(1), 271-274.e2. https://doi.org/10.1053/j.gastro.2023.03.198

@article{a74e1b3572a44de9b8cbf96aed342549,

title = "Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas",

author = "Helderman, \{Noah c.\} and \{Van Der Werf-{\textquoteright}T Lam\}, \{Anne Sophie\} and Diantha Terlouw and \{Bajwa-ten Broeke\}, \{Sanne W.\} and Mar Rodr{\'i}guez-Girondo and \{van Egmond\}, Demi and Langers, \{Alexandra M.J.\} and \{van Leerdam\}, \{Monique E.\} and Emily Rayner and \{van Asperen\}, \{Christi J.\} and \{van Hest\}, \{Liselotte P.\} and Gille, \{Hans J.P.\} and Duijkers, \{Floor A.M.\} and Anja Wagner and Eikenboom, \{Ellis L.\} and Letteboer, \{Tom G.W.\} and \{de Jong\}, \{Mirjam M.\} and Bleeker, \{Fonnet E.\} and \{Gomez Garc{\`i}a\}, \{Encarna B.\} and Manon Suerink and Tops, \{Carli M.\} and \{de Wind\}, Niels and Hans Morreau and Arnoud Boot and \{Van Wezel\}, Tom and Maartje Nielsen and \{MSH6 TUMOR GROUP\}",

note = "Funding Information: Members of the MSH6 Tumor Group are as follows: Diantha Terlouw,1,2 Sanne W. Bajwa-ten Broeke,3 Mar Rodr{\'i}guez-Girondo,4 Demi van Egmond,2 Alexandra M. J. Langers,5 Monique E. van Leerdam,5,6 Emily Rayner,7 Christi J. van Asperen,1 Liselotte P. van Hest,8 Hans J. P. Gille,8 Floor A. M. Duijkers,9 Anja Wagner,10 Ellis L. Eikenboom,10,11 Tom G. W. Letteboer,12 Mirjam M. de Jong,3 Fonnet E. Bleeker,13 Encarna B. Gomez Garc{\`i}a,14 Manon Suerink,1 Carli M. Tops,1 Niels de Wind7; from the 1Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands; 2Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; 3Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 4Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands; 5Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands; 6Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands; 7Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; 8Department of Clinical Genetics, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam and location University of Amsterdam, Amsterdam, The Netherlands; 9Department of Human Genetics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 10Department of Clinical Genetics, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands; 11Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands; 12Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands; 13Department of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands; 14Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. The authors sincerely thank all patients and their families for their participation in this study. We gratefully acknowledge the editing assistance of MedicalEditing.nl and the support from the participating pathology centers. Noah Cornelis Helderman, BSc, PhD candidate (Formal analysis: Lead; Investigation: Lead; Methodology: Equal; Visualization: Lead; Writing – original draft: Lead; Writing – review \& editing: Lead). Anne-Sophie van der Werf-'t Lam, MD, PhD candidate (Formal analysis: Supporting; Methodology: Supporting; Writing – original draft: Supporting; Writing – review \& editing: Equal). Diantha Terlouw, MSc, PhD candidate (Formal analysis: Supporting; Investigation: Supporting; Writing – review \& editing: Equal). Sanne W. Bajwa-ten Broeke, MD, PhD (Formal analysis: Supporting; Investigation: Supporting; Writing – review \& editing: Equal). Mar Rodr{\'i}guez-Girondo, PhD (Methodology: Supporting; Writing – review \& editing: Equal). Demi van Egmond (Formal analysis: Supporting; Investigation: Supporting; Writing – review \& editing: Supporting). Alexandra M. J. Langers, MD, PhD (Writing – review \& editing: Equal). Monique E. van Leerdam, MD, PhD (Writing – review \& editing: Equal). Emily Rayner, PhD (Writing – review \& editing: Equal). Christi J. van Asperen, MD, PhD (Writing – review \& editing: Equal). Liselotte P. van hest, MD (Writing – review \& editing: Supporting). Hans J. P. Gille, PhD (Writing – review \& editing: Supporting). Floor A. M. Duijkers, MD, PhD (Writing – review \& editing: Supporting). Anja Wagner, MD, PhD (Writing – review \& editing: Supporting). Ellis L. Eikenboom, PhD candidate (Writing – review \& editing: Supporting). Tom G. W. Letteboer, PhD (Writing – review \& editing: Supporting). Mirjam M. de Jong, MD, PhD (Writing – review \& editing: Supporting). Fonnet E. Bleeker, MD, PhD (Writing – review \& editing: Supporting). Encarna B. Gomez Garc{\`i}a, MD, PhD (Writing – review \& editing: Supporting). Manon Suerink, MD, PhD (Writing – review \& editing: Equal). Carli M. Tops, PhD (Writing – review \& editing: Equal). Niels de Wind, PhD (Writing – review \& editing: Equal). Hans Morreau, MD, PhD (Conceptualization: Equal; Formal analysis: Equal; Investigation: Equal; Methodology: Equal; Writing – review \& editing: Equal). Arnoud Boot, PhD (Formal analysis: Equal; Investigation: Equal; Methodology: Equal; Writing – review \& editing: Equal). Tom van Wezel, PhD (Conceptualization: Equal; Formal analysis: Equal; Investigation: Equal; Methodology: Equal; Writing – review \& editing: Equal). Maartje Nielsen, MD, PhD (Conceptualization: Lead; Formal analysis: Equal; Funding acquisition: Lead; Investigation: Equal; Methodology: Equal; Project administration: Lead; Supervision: Lead; Writing – original draft: Supporting; Writing – review \& editing: Equal). Funding This study was funded by the MLDS (Dutch Digestive Disease foundation, grant no. FP16-06). The funder had no role in the study design, data acquisition and analysis, decision to publish, or preparation of the manuscript. Funding Information: Funding This study was funded by the MLDS (Dutch Digestive Disease foundation, grant no. FP16-06). The funder had no role in the study design, data acquisition and analysis, decision to publish, or preparation of the manuscript.",

year = "2023",

month = jul,

day = "1",

doi = "10.1053/j.gastro.2023.03.198",

language = "English",

volume = "165",

pages = "271--274.e2",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "1",

}

Helderman, NC, Van Der Werf-’T Lam, AS, Terlouw, D, Bajwa-ten Broeke, SW, Rodríguez-Girondo, M, van Egmond, D, Langers, AMJ, van Leerdam, ME, Rayner, E, van Asperen, CJ, van Hest, LP, Gille, HJP, Duijkers, FAM, Wagner, A, Eikenboom, EL, Letteboer, TGW, de Jong, MM, Bleeker, FE, Gomez Garcìa, EB, Suerink, M, Tops, CM, de Wind, N, Morreau, H, Boot, A, Van Wezel, T, Nielsen, M & MSH6 TUMOR GROUP 2023, 'Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas', Gastroenterology, vol. 165, no. 1, pp. 271-274.e2. https://doi.org/10.1053/j.gastro.2023.03.198

Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas. / Helderman, Noah c.; Van Der Werf-’T Lam, Anne Sophie; Terlouw, Diantha et al.
In: Gastroenterology, Vol. 165, No. 1, 01.07.2023, p. 271-274.e2.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome–Associated Colorectal Carcinomas

AU - Helderman, Noah c.

AU - Van Der Werf-’T Lam, Anne Sophie

AU - Terlouw, Diantha

AU - Bajwa-ten Broeke, Sanne W.

AU - Rodríguez-Girondo, Mar

AU - van Egmond, Demi

AU - Langers, Alexandra M.J.

AU - van Leerdam, Monique E.

AU - Rayner, Emily

AU - van Asperen, Christi J.

AU - van Hest, Liselotte P.

AU - Gille, Hans J.P.

AU - Duijkers, Floor A.M.

AU - Wagner, Anja

AU - Eikenboom, Ellis L.

AU - Letteboer, Tom G.W.

AU - de Jong, Mirjam M.

AU - Bleeker, Fonnet E.

AU - Gomez Garcìa, Encarna B.

AU - Suerink, Manon

AU - Tops, Carli M.

AU - de Wind, Niels

AU - Morreau, Hans

AU - Boot, Arnoud

AU - Van Wezel, Tom

AU - Nielsen, Maartje

AU - MSH6 TUMOR GROUP

N1 - Funding Information: Members of the MSH6 Tumor Group are as follows: Diantha Terlouw,1,2 Sanne W. Bajwa-ten Broeke,3 Mar Rodríguez-Girondo,4 Demi van Egmond,2 Alexandra M. J. Langers,5 Monique E. van Leerdam,5,6 Emily Rayner,7 Christi J. van Asperen,1 Liselotte P. van Hest,8 Hans J. P. Gille,8 Floor A. M. Duijkers,9 Anja Wagner,10 Ellis L. Eikenboom,10,11 Tom G. W. Letteboer,12 Mirjam M. de Jong,3 Fonnet E. Bleeker,13 Encarna B. Gomez Garcìa,14 Manon Suerink,1 Carli M. Tops,1 Niels de Wind7; from the 1Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands; 2Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; 3Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 4Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands; 5Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands; 6Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands; 7Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; 8Department of Clinical Genetics, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam and location University of Amsterdam, Amsterdam, The Netherlands; 9Department of Human Genetics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 10Department of Clinical Genetics, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands; 11Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands; 12Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands; 13Department of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands; 14Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. The authors sincerely thank all patients and their families for their participation in this study. We gratefully acknowledge the editing assistance of MedicalEditing.nl and the support from the participating pathology centers. Noah Cornelis Helderman, BSc, PhD candidate (Formal analysis: Lead; Investigation: Lead; Methodology: Equal; Visualization: Lead; Writing – original draft: Lead; Writing – review & editing: Lead). Anne-Sophie van der Werf-'t Lam, MD, PhD candidate (Formal analysis: Supporting; Methodology: Supporting; Writing – original draft: Supporting; Writing – review & editing: Equal). Diantha Terlouw, MSc, PhD candidate (Formal analysis: Supporting; Investigation: Supporting; Writing – review & editing: Equal). Sanne W. Bajwa-ten Broeke, MD, PhD (Formal analysis: Supporting; Investigation: Supporting; Writing – review & editing: Equal). Mar Rodríguez-Girondo, PhD (Methodology: Supporting; Writing – review & editing: Equal). Demi van Egmond (Formal analysis: Supporting; Investigation: Supporting; Writing – review & editing: Supporting). Alexandra M. J. Langers, MD, PhD (Writing – review & editing: Equal). Monique E. van Leerdam, MD, PhD (Writing – review & editing: Equal). Emily Rayner, PhD (Writing – review & editing: Equal). Christi J. van Asperen, MD, PhD (Writing – review & editing: Equal). Liselotte P. van hest, MD (Writing – review & editing: Supporting). Hans J. P. Gille, PhD (Writing – review & editing: Supporting). Floor A. M. Duijkers, MD, PhD (Writing – review & editing: Supporting). Anja Wagner, MD, PhD (Writing – review & editing: Supporting). Ellis L. Eikenboom, PhD candidate (Writing – review & editing: Supporting). Tom G. W. Letteboer, PhD (Writing – review & editing: Supporting). Mirjam M. de Jong, MD, PhD (Writing – review & editing: Supporting). Fonnet E. Bleeker, MD, PhD (Writing – review & editing: Supporting). Encarna B. Gomez Garcìa, MD, PhD (Writing – review & editing: Supporting). Manon Suerink, MD, PhD (Writing – review & editing: Equal). Carli M. Tops, PhD (Writing – review & editing: Equal). Niels de Wind, PhD (Writing – review & editing: Equal). Hans Morreau, MD, PhD (Conceptualization: Equal; Formal analysis: Equal; Investigation: Equal; Methodology: Equal; Writing – review & editing: Equal). Arnoud Boot, PhD (Formal analysis: Equal; Investigation: Equal; Methodology: Equal; Writing – review & editing: Equal). Tom van Wezel, PhD (Conceptualization: Equal; Formal analysis: Equal; Investigation: Equal; Methodology: Equal; Writing – review & editing: Equal). Maartje Nielsen, MD, PhD (Conceptualization: Lead; Formal analysis: Equal; Funding acquisition: Lead; Investigation: Equal; Methodology: Equal; Project administration: Lead; Supervision: Lead; Writing – original draft: Supporting; Writing – review & editing: Equal). Funding This study was funded by the MLDS (Dutch Digestive Disease foundation, grant no. FP16-06). The funder had no role in the study design, data acquisition and analysis, decision to publish, or preparation of the manuscript. Funding Information: Funding This study was funded by the MLDS (Dutch Digestive Disease foundation, grant no. FP16-06). The funder had no role in the study design, data acquisition and analysis, decision to publish, or preparation of the manuscript.

PY - 2023/7/1

Y1 - 2023/7/1

U2 - 10.1053/j.gastro.2023.03.198

DO - 10.1053/j.gastro.2023.03.198

M3 - Article

SN - 0016-5085

VL - 165

SP - 271-274.e2

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -