Molecular imaging in the combined modality treatment of lung cancer

J.G.M. van Loon

doi:10.26481/dis.20101022jl

Molecular imaging in the combined modality treatment of lung cancer

J.G.M. van Loon

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Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Patients with locally advanced lung cancer receive a combined treatment of radiotherapy and chemotherapy. This dissertation studied how this treatment can be optimized by means of molecular imaging with positron emission tomography (PET). The results show that the radiation area of small-cell lung cancer can be diminished safely by using the PET scan. It is further shown that, 3 months after the treatment, a PET scan can determine the progression of the disease in a stage when re-treatment is still possible. Finally, 2 new PET tracers are evaluated, aimed at specific biological characteristics of cancer cells. The studies show that these tracers can be safely used. Future studies will be necessary to define the optimal imaging circumstances.

This research received partial support from ‘KWF kankerbestrijding’.
lung cancer

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	de Ruysscher, Dirk, Supervisor Lambin, Philippe, Supervisor Boersma, Liesbeth, Co-Supervisor
Award date	22 Oct 2010
Place of Publication	Maastricht
Publisher	Datawyse / Universitaire Pers Maastricht
Print ISBNs	9789052789736
DOIs	https://doi.org/10.26481/dis.20101022jl
Publication status	Published - 1 Jan 2010

Keywords

lung cancer
PET
radiotherapy

Access to Document

10.26481/dis.20101022jl

Full TextFinal published version, 4.4 MB
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Cite this

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AB - Patients with locally advanced lung cancer receive a combined treatment of radiotherapy and chemotherapy. This dissertation studied how this treatment can be optimized by means of molecular imaging with positron emission tomography (PET). The results show that the radiation area of small-cell lung cancer can be diminished safely by using the PET scan. It is further shown that, 3 months after the treatment, a PET scan can determine the progression of the disease in a stage when re-treatment is still possible. Finally, 2 new PET tracers are evaluated, aimed at specific biological characteristics of cancer cells. The studies show that these tracers can be safely used. Future studies will be necessary to define the optimal imaging circumstances. This research received partial support from ‘KWF kankerbestrijding’.lung cancer

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