Molecular imaging in the combined modality treatment of lung cancer

Research output: ThesisDoctoral ThesisInternal

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Abstract

Patients with locally advanced lung cancer receive a combined treatment of radiotherapy and chemotherapy. This dissertation studied how this treatment can be optimized by means of molecular imaging with positron emission tomography (PET). The results show that the radiation area of small-cell lung cancer can be diminished safely by using the PET scan. It is further shown that, 3 months after the treatment, a PET scan can determine the progression of the disease in a stage when re-treatment is still possible. Finally, 2 new PET tracers are evaluated, aimed at specific biological characteristics of cancer cells. The studies show that these tracers can be safely used. Future studies will be necessary to define the optimal imaging circumstances.

This research received partial support from ‘KWF kankerbestrijding’.
lung cancer
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • de Ruysscher, Dirk, Supervisor
  • Lambin, Philippe, Supervisor
  • Boersma, Liesbeth, Advisor
Award date22 Oct 2010
Place of PublicationMaastricht
Publisher
Print ISBNs9789052789736
Publication statusPublished - 1 Jan 2010

Keywords

  • lung cancer
  • PET
  • radiotherapy

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