Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex

A. Vallès, I. Granic, P. de Weerd, G.J.M. Martens

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Modulation of cortical network connectivity is crucial for an adaptive response to experience. In the rat barrel cortex, long-term sensory stimulation induces cortical network modifications and neuronal response changes of which the molecular basis is unknown. Here, we show that long-term somatosensory stimulation by enriched environment up-regulates cortical expression of neuropeptide mRNAs and down-regulates immediate-early gene (IEG) mRNAs specifically in the barrel cortex, and not in other brain regions. The present data suggest a central role of neuropeptides in the fine-tuning of sensory cortical circuits by long-term experience.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalLearning & Memory
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2014

Keywords

  • ACTIVATING POLYPEPTIDE PACAP
  • CENTRAL-NERVOUS-SYSTEM
  • CORTICOTROPIN-RELEASING HORMONE
  • DEPENDENT PLASTICITY
  • GLUTAMATE-DECARBOXYLASE
  • IN-SITU HYBRIDIZATION
  • LYSYL OXIDASE PROPEPTIDE
  • NEOCORTICAL INTERNEURONS
  • NEUROPEPTIDE-Y
  • SYNAPTIC-TRANSMISSION

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