Molecular complexity of voltage-gated sodium channels: theory and applications in mutation-response prediction

Markos Xenakis

Research output: ThesisDoctoral ThesisInternal

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Abstract

Ion channels are information transmitters of living cells. Ion channel defects appear in a broad range of diseases including epilepsy, migraine, diabetes, hypertension, cardiac arrhythmia, and neuropathic pain. One of the scopes of biomedical research targeting ion channels is to improve diagnostics and develop therapeutic agents and strategies for counteraction, or at least, management of aforementioned diseases. This dissertation focussed on a specific type of ion channels, namely, on voltage-gated sodium channels (VGSCs), which are known to play a key-role in human pain pathophysiology. Results and findings of this dissertation provide novel insights into how VGSCs remain functionally stable within the cell membrane, as well as, into how genetically-caused defects affecting VGSC structure relate to neuropathic pain disease.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Smeets, Bert, Supervisor
  • Westra, Ronald, Co-Supervisor
  • Lindsey, Patrick, Co-Supervisor
Award date26 May 2021
Place of PublicationMaastricht
Publisher
Print ISBNs9789464232608
DOIs
Publication statusPublished - 2021

Keywords

  • voltage-gated sodium channels
  • complexity
  • pain medicine
  • pain genetics
  • variants prediction

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