Mold-Based Application of Laser-Induced Periodic Surface Structures (LIPSS) on Biomaterials for Nanoscale Patterning

Wim Hendrikson, Wendy Masman-Bakker, Bas van Bochove, Johann Skolski, Justus Eichstadt, Bart Koopman, Clemens van Blitterswijk, Dirk Grijpma, Gert-Willem Romer, Lorenzo Moroni, Jeroen Rouwkema*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Laser-induced periodic surface structures (LIPSS) are highly regular, but at the same time contain a certain level of disorder. The application of LIPSS is a promising method to functionalize biomaterials. However, the absorption of laser energy of most polymer biomaterials is insufficient for the direct application of LIPSS. Here, we report the application of LIPSS to relevant biomaterials using a two-step approach. First, LIPSS are fabricated on a stainless steel surface. Then, the structures are replicated onto biomaterials using the steel as a mold. Results show that LIPSS can be transferred successfully using this approach, and that human mesenchymal stromal cells respond to the transferred structures. With this approach, the range of biomaterials that can be supplied with LIPSS increases dramatically.
Original languageEnglish
Pages (from-to)43-49
JournalMacromolecular Bioscience
Issue number1
Publication statusPublished - Jan 2016

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