Modulation of vascular inflammation: cell type specific effects by ADAMs and HDL

Research output: ThesisDoctoral ThesisInternal

115 Downloads (Pure)

Abstract

Atherosclerosis is the main cause of cardiovascular disease. This dissertation focuses on regulating inflammation, a key factor in atherosclerosis, by modulating high density lipoproteins (HDL, or ‘good cholesterol’) and modifying proteins via A Disintegrin And Metalloprotease (ADAM) enzymes. We demonstrated that the presence of ADAM10 in blood cells and endothelial cells has the opposite effect on atherosclerosis. We also found that HDL had cell-specific effects, namely, anti-inflammatory effects on smooth muscle cells and inflammatory effects on macrophages. These cell-specific effects are important for developing targeted and patient-specific therapies.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Biessen, Erik, Supervisor
  • de Winther, Menno, Supervisor
  • Glatz, Jan, Supervisor
  • Donnors, M.M.P.C., Advisor, External person
Award date21 May 2015
Place of PublicationMaastricht
Publisher
Print ISBNs9789462951655
Publication statusPublished - 2015

Keywords

  • atherosclerosis
  • inflammation
  • enzymes

Cite this