Modulating Alginate Hydrogels for Improved Biological Performance as Cellular 3D Microenvironments

Mariana Isabel Neves, Lorenzo Moroni, Cristina Carvalho Barrias*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

36 Citations (Web of Science)

Abstract

The rational choice and design of biomaterials for biomedical applications is crucial for successfulin vitroandin vivostrategies, ultimately dictating their performance and potential clinical applications. Alginate, a marine-derived polysaccharide obtained from seaweeds, is one of the most widely used polymers in the biomedical field, particularly to build three dimensional (3D) systems forin vitroculture andin vivodelivery of cells. Despite their biocompatibility, alginate hydrogels often require modifications to improve their biological activity, namely via inclusion of mammalian cell-interactive domains and fine-tuning of mechanical properties. These modifications enable the addition of new features for greater versatility and control over alginate-based systems, extending the plethora of applications and procedures where they can be used. Additionally, hybrid systems based on alginate combination with other components can also be explored to improve the mimicry of extracellular microenvironments and their dynamics. This review provides an overview on alginate properties and current clinical applications, along with different strategies that have been reported to improve alginate hydrogels performance as 3D matrices and 4D dynamic systems.

Original languageEnglish
Article number665
Number of pages16
JournalFrontiers in bioengineering and biotechnology
Volume8
DOIs
Publication statusPublished - 30 Jun 2020

Keywords

  • alginate
  • biomaterial
  • biofunctionalization
  • 3D cell culture
  • 4D systems
  • MESENCHYMAL STEM-CELLS
  • SPACER ARM LENGTH
  • EXTRACELLULAR-MATRIX
  • ADHESION LIGAND
  • ISLET XENOTRANSPLANTATION
  • SULFATED POLYSACCHARIDES
  • COMPOSITE HYDROGELS
  • SUBSTRATE STIFFNESS
  • STRESS-RELAXATION
  • PECTIN HYDROGELS

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