Modified swim test as a mouse depression paradigm of enhanced cognitive processing: the role of GSK3β

Nataliia Markova

doi:10.26481/dis.20170502nm

Modified swim test as a mouse depression paradigm of enhanced cognitive processing: the role of GSK3β

Nataliia Markova

Research output: Thesis › Doctoral Thesis › External prepared

1995 Downloads (Pure)

Abstract

The neurobiology and involvement of glycogen synthase kinase 3 beta in individual susceptibility to depression was studied in a new model of enhanced memory of adversity. It was shown for the first time, that diiodothyronine hormone, vitamin B1 and its precursor benfotiamine have an antidepressant effect. That suggests their use as supplementary therapy. Also, the antidepressant imipramine used in much lower doses than commonly, prevented depressive-like changes of mice. This can help to refine the dose of this antidepressant in the clinical practice.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Steinbusch, Harry, Supervisor Lesch, Klaus-Peter, Supervisor Strekalova, Tatiana, Co-Supervisor
Award date	2 May 2017
Place of Publication	Maastricht
Publisher	Maastricht University
DOIs	https://doi.org/10.26481/dis.20170502nm
Publication status	Published - 2017

Keywords

depression
individual susceptibility
diiodothyronine hormone
vitamin B1
benfotiamine
antidepressants

Access to Document

10.26481/dis.20170502nm

Full textFinal published version, 4.54 MBLicence: Unspecified
AbstractFinal published version, 275 KBLicence: Unspecified
PropositionsFinal published version, 302 KBLicence: Unspecified
CoverFinal published version, 2.09 MBLicence: Unspecified
ValorisationFinal published version, 357 KBLicence: Unspecified

Cite this

@phdthesis{069721255b3946f6955906d2ec6bb38c,

title = "Modified swim test as a mouse depression paradigm of enhanced cognitive processing: the role of GSK3β",

abstract = "The neurobiology and involvement of glycogen synthase kinase 3 beta in individual susceptibility to depression was studied in a new model of enhanced memory of adversity. It was shown for the first time, that diiodothyronine hormone, vitamin B1 and its precursor benfotiamine have an antidepressant effect. That suggests their use as supplementary therapy. Also, the antidepressant imipramine used in much lower doses than commonly, prevented depressive-like changes of mice. This can help to refine the dose of this antidepressant in the clinical practice.",

keywords = "depression, individual susceptibility, diiodothyronine hormone, vitamin B1, benfotiamine, antidepressants",

author = "Nataliia Markova",

year = "2017",

doi = "10.26481/dis.20170502nm",

language = "English",

publisher = "Maastricht University",

address = "Netherlands",

school = "Maastricht University",

}

TY - BOOK

T1 - Modified swim test as a mouse depression paradigm of enhanced cognitive processing

T2 - the role of GSK3β

AU - Markova, Nataliia

PY - 2017

Y1 - 2017

N2 - The neurobiology and involvement of glycogen synthase kinase 3 beta in individual susceptibility to depression was studied in a new model of enhanced memory of adversity. It was shown for the first time, that diiodothyronine hormone, vitamin B1 and its precursor benfotiamine have an antidepressant effect. That suggests their use as supplementary therapy. Also, the antidepressant imipramine used in much lower doses than commonly, prevented depressive-like changes of mice. This can help to refine the dose of this antidepressant in the clinical practice.

AB - The neurobiology and involvement of glycogen synthase kinase 3 beta in individual susceptibility to depression was studied in a new model of enhanced memory of adversity. It was shown for the first time, that diiodothyronine hormone, vitamin B1 and its precursor benfotiamine have an antidepressant effect. That suggests their use as supplementary therapy. Also, the antidepressant imipramine used in much lower doses than commonly, prevented depressive-like changes of mice. This can help to refine the dose of this antidepressant in the clinical practice.

KW - depression

KW - individual susceptibility

KW - diiodothyronine hormone

KW - vitamin B1

KW - benfotiamine

KW - antidepressants

U2 - 10.26481/dis.20170502nm

DO - 10.26481/dis.20170502nm

M3 - Doctoral Thesis

PB - Maastricht University

CY - Maastricht

ER -

Modified swim test as a mouse depression paradigm of enhanced cognitive processing: the role of GSK3β

Abstract

Keywords

Access to Document

Fingerprint

Cite this