Modes and strategies for providing conventional mechanical ventilation in neonates

Anton H van Kaam*, Danièla De Luca, Roland Hentschel, Jeroen Hutten, Richard Sindelar, Ulrich Thome, Luc J I Zimmermann

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


Neonatal respiratory failure is a common and serious clinical problem which in a considerable proportion of infants requires invasive mechanical ventilation. The basic goal of mechanical ventilation is to restore lung function while limiting ventilator-induced lung injury, which is considered an important risk factor in the development of bronchopulmonary dysplasia (BPD). Over the last decades, new conventional mechanical ventilation (CMV) modalities have been introduced in clinical practice, aiming to assist clinicians in providing lung protective ventilation strategies. These modalities use more sophisticated techniques to improve patient-ventilator interaction and transfer control of ventilation from the operator to the patient. Knowledge on how these new modalities work and how they interact with lung physiology is essential for optimal and safe use. In this review, we will discuss some important basic lung physiological aspects for applying CMV, the basic principles of the old and new CMV modalities, and the evidence to support their use in daily clinical practice.

Original languageEnglish
Pages (from-to)957–962
JournalPediatric Research
Early online date30 Nov 2019
Publication statusPublished - Nov 2021


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