TY - JOUR
T1 - Modern Treatment of Rectal Cancer Closes the Gap Between Common Adenocarcinoma and Mucinous Carcinoma
AU - Hugen, Niek
AU - van de Velde, Cornelis J.
AU - Bosch, Steven L.
AU - Futterer, Jurgen J.
AU - Elferink, Marloes A.
AU - Marijnen, Corrie A.
AU - Rutten, Harm J.
AU - de Wilt, Johannes H.
AU - Nagtegaal, Iris D.
PY - 2015/8
Y1 - 2015/8
N2 - Mucinous carcinoma (MC) is a distinct form of rectal cancer (RC) comprising 10?% of all cases and has been associated with an impaired prognosis compared with non-mucinous adenocarcinoma (AC). The benefit of today's modern treatment for MC patients is unknown but a prospective randomized trial to answer this does not seem feasible. This study provides an analysis of the modern treatment of rectal MC and efficacy of preoperative therapies for MC patients.Data from three large (trial) cohorts were used. Data from the Netherlands Cancer Registry (NCR) were used to analyze the prognosis of RC patients over time (N?=?38,035). To study the benefit of preoperative short-term radiotherapy, patients from the total mesorectal excision (TME) trial (N?=?1,530) were selected, and the benefit from preoperative chemoradiotherapy was analyzed with data on 540 locally advanced RC (LARC) patients from two hospitals.Data from the NCR confirmed that 5-year overall survival for MC was significantly worse from 1989 to 1998, but no longer different from AC from 1999 onwards. MC patients had a higher rate of positive circumferential resection margin than AC patients (TME trial 27.2 vs. 16.5?%, p?=?0.006; LARC cohort 34.5 vs. 9.8?%, p?
AB - Mucinous carcinoma (MC) is a distinct form of rectal cancer (RC) comprising 10?% of all cases and has been associated with an impaired prognosis compared with non-mucinous adenocarcinoma (AC). The benefit of today's modern treatment for MC patients is unknown but a prospective randomized trial to answer this does not seem feasible. This study provides an analysis of the modern treatment of rectal MC and efficacy of preoperative therapies for MC patients.Data from three large (trial) cohorts were used. Data from the Netherlands Cancer Registry (NCR) were used to analyze the prognosis of RC patients over time (N?=?38,035). To study the benefit of preoperative short-term radiotherapy, patients from the total mesorectal excision (TME) trial (N?=?1,530) were selected, and the benefit from preoperative chemoradiotherapy was analyzed with data on 540 locally advanced RC (LARC) patients from two hospitals.Data from the NCR confirmed that 5-year overall survival for MC was significantly worse from 1989 to 1998, but no longer different from AC from 1999 onwards. MC patients had a higher rate of positive circumferential resection margin than AC patients (TME trial 27.2 vs. 16.5?%, p?=?0.006; LARC cohort 34.5 vs. 9.8?%, p?
U2 - 10.1245/s10434-014-4339-5
DO - 10.1245/s10434-014-4339-5
M3 - Article
C2 - 25564178
SN - 1068-9265
VL - 22
SP - 2669
EP - 2676
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 8
ER -