Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis

Kirsten van de Groep; Martine P. Bos; Meri R. J. Varkila; Paul H. M. Savelkoul; David S. Y. Ong; Lennie P. G. Derde; Nicole P. Juffermans; Marc J. M. Bonten; Olaf L. Cremer; Friso M. de Beer; Lieuwe D. J. Bos; Gerie J. Glas; Arie J. Hoogendijk; Roosmarijn T. M. van Hooijdonk; Janneke Horn; Mischa A. Huson; Tom van der Poll; Laura R. A. Schouten; Brendon Scicluna; Marcus J. Schultz; Marleen Straat; Lonneke A. van Vught; Luuk Wieske; Maryse A. Wiewel; Esther Witteveen; Jos F. Frencken; Peter M. C. Klein Klouwenberg; Maria E. Koster-Brouwer; Meri R. J. Varkila; Diana M. Verboom; MARS Consortium

doi:10.1007/s10096-019-03616-w

Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis

Kirsten van de Groep^*, Martine P. Bos, Meri R. J. Varkila, Paul H. M. Savelkoul, David S. Y. Ong, Lennie P. G. Derde, Nicole P. Juffermans, Marc J. M. Bonten, Olaf L. Cremer, Friso M. de Beer, Lieuwe D. J. Bos, Gerie J. Glas, Arie J. Hoogendijk, Roosmarijn T. M. van Hooijdonk, Janneke Horn, Mischa A. Huson, Tom van der Poll, Laura R. A. Schouten, Brendon Scicluna, Marcus J. SchultzMarleen Straat, Lonneke A. van Vught, Luuk Wieske, Maryse A. Wiewel, Esther Witteveen, Jos F. Frencken, Peter M. C. Klein Klouwenberg, Maria E. Koster-Brouwer, Meri R. J. Varkila, Diana M. Verboom, MARS Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Web of Science)

Original language	English
Pages (from-to)	1829-1836
Number of pages	8
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	38
Issue number	10
DOIs	https://doi.org/10.1007/s10096-019-03616-w
Publication status	Published - Oct 2019

Keywords

Diagnostic research
Pathogen detection
Sepsis
Intensive care
Multiplex real-time PCR
INFECTIONS

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10.1007/s10096-019-03616-w

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van de Groep, K., Bos, M. P., Varkila, M. R. J., Savelkoul, P. H. M., Ong, D. S. Y., Derde, L. P. G., Juffermans, N. P., Bonten, M. J. M., Cremer, O. L., de Beer, F. M., Bos, L. D. J., Glas, G. J., Hoogendijk, A. J., van Hooijdonk, R. T. M., Horn, J., Huson, M. A., van der Poll, T., Schouten, L. R. A., Scicluna, B., ... MARS Consortium (2019). Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis. European Journal of Clinical Microbiology & Infectious Diseases, 38(10), 1829-1836. https://doi.org/10.1007/s10096-019-03616-w

van de Groep, Kirsten ; Bos, Martine P. ; Varkila, Meri R. J. ; Savelkoul, Paul H. M. ; Ong, David S. Y. ; Derde, Lennie P. G. ; Juffermans, Nicole P. ; Bonten, Marc J. M. ; Cremer, Olaf L. ; de Beer, Friso M. ; Bos, Lieuwe D. J. ; Glas, Gerie J. ; Hoogendijk, Arie J. ; van Hooijdonk, Roosmarijn T. M. ; Horn, Janneke ; Huson, Mischa A. ; van der Poll, Tom ; Schouten, Laura R. A. ; Scicluna, Brendon ; Schultz, Marcus J. ; Straat, Marleen ; van Vught, Lonneke A. ; Wieske, Luuk ; Wiewel, Maryse A. ; Witteveen, Esther ; Frencken, Jos F. ; Klouwenberg, Peter M. C. Klein ; Koster-Brouwer, Maria E. ; Varkila, Meri R. J. ; Verboom, Diana M. ; MARS Consortium. / Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis. In: European Journal of Clinical Microbiology & Infectious Diseases. 2019 ; Vol. 38, No. 10. pp. 1829-1836.

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title = "Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis",

keywords = "Diagnostic research, Pathogen detection, Sepsis, Intensive care, Multiplex real-time PCR, INFECTIONS",

author = "{van de Groep}, Kirsten and Bos, {Martine P.} and Varkila, {Meri R. J.} and Savelkoul, {Paul H. M.} and Ong, {David S. Y.} and Derde, {Lennie P. G.} and Juffermans, {Nicole P.} and Bonten, {Marc J. M.} and Cremer, {Olaf L.} and {de Beer}, {Friso M.} and Bos, {Lieuwe D. J.} and Glas, {Gerie J.} and Hoogendijk, {Arie J.} and {van Hooijdonk}, {Roosmarijn T. M.} and Janneke Horn and Huson, {Mischa A.} and {van der Poll}, Tom and Schouten, {Laura R. A.} and Brendon Scicluna and Schultz, {Marcus J.} and Marleen Straat and {van Vught}, {Lonneke A.} and Luuk Wieske and Wiewel, {Maryse A.} and Esther Witteveen and Frencken, {Jos F.} and Klouwenberg, {Peter M. C. Klein} and Koster-Brouwer, {Maria E.} and Varkila, {Meri R. J.} and Verboom, {Diana M.} and {MARS Consortium}",

year = "2019",

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van de Groep, K, Bos, MP, Varkila, MRJ, Savelkoul, PHM, Ong, DSY, Derde, LPG, Juffermans, NP, Bonten, MJM, Cremer, OL, de Beer, FM, Bos, LDJ, Glas, GJ, Hoogendijk, AJ, van Hooijdonk, RTM, Horn, J, Huson, MA, van der Poll, T, Schouten, LRA, Scicluna, B, Schultz, MJ, Straat, M, van Vught, LA, Wieske, L, Wiewel, MA, Witteveen, E, Frencken, JF, Klouwenberg, PMCK, Koster-Brouwer, ME, Varkila, MRJ, Verboom, DM & MARS Consortium 2019, 'Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis', European Journal of Clinical Microbiology & Infectious Diseases, vol. 38, no. 10, pp. 1829-1836. https://doi.org/10.1007/s10096-019-03616-w

Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis. / van de Groep, Kirsten; Bos, Martine P.; Varkila, Meri R. J.; Savelkoul, Paul H. M.; Ong, David S. Y.; Derde, Lennie P. G.; Juffermans, Nicole P.; Bonten, Marc J. M.; Cremer, Olaf L.; de Beer, Friso M.; Bos, Lieuwe D. J.; Glas, Gerie J.; Hoogendijk, Arie J.; van Hooijdonk, Roosmarijn T. M.; Horn, Janneke; Huson, Mischa A.; van der Poll, Tom; Schouten, Laura R. A.; Scicluna, Brendon; Schultz, Marcus J.; Straat, Marleen; van Vught, Lonneke A.; Wieske, Luuk; Wiewel, Maryse A.; Witteveen, Esther; Frencken, Jos F.; Klouwenberg, Peter M. C. Klein; Koster-Brouwer, Maria E.; Varkila, Meri R. J.; Verboom, Diana M.; MARS Consortium.

In: European Journal of Clinical Microbiology & Infectious Diseases, Vol. 38, No. 10, 10.2019, p. 1829-1836.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis

AU - van de Groep, Kirsten

AU - Bos, Martine P.

AU - Varkila, Meri R. J.

AU - Savelkoul, Paul H. M.

AU - Ong, David S. Y.

AU - Derde, Lennie P. G.

AU - Juffermans, Nicole P.

AU - Bonten, Marc J. M.

AU - Cremer, Olaf L.

AU - de Beer, Friso M.

AU - Bos, Lieuwe D. J.

AU - Glas, Gerie J.

AU - Hoogendijk, Arie J.

AU - van Hooijdonk, Roosmarijn T. M.

AU - Horn, Janneke

AU - Huson, Mischa A.

AU - van der Poll, Tom

AU - Schouten, Laura R. A.

AU - Scicluna, Brendon

AU - Schultz, Marcus J.

AU - Straat, Marleen

AU - van Vught, Lonneke A.

AU - Wieske, Luuk

AU - Wiewel, Maryse A.

AU - Witteveen, Esther

AU - Frencken, Jos F.

AU - Klouwenberg, Peter M. C. Klein

AU - Koster-Brouwer, Maria E.

AU - Varkila, Meri R. J.

AU - Verboom, Diana M.

AU - MARS Consortium

PY - 2019/10

Y1 - 2019/10

KW - Diagnostic research

KW - Pathogen detection

KW - Sepsis

KW - Intensive care

KW - Multiplex real-time PCR

KW - INFECTIONS

U2 - 10.1007/s10096-019-03616-w

DO - 10.1007/s10096-019-03616-w

M3 - Article

C2 - 31243596

VL - 38

SP - 1829

EP - 1836

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

SN - 0934-9723

IS - 10

ER -