Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

Sabine van Oort*, Joline W. Beulens, Amber A. W. A. van der Heijden, Petra J. M. Elders, Coen D. A. Stehouwer, Inge A. T. van de Luitgaarden, Ilse C. Schrieks, Diederick E. Grobbee, Adriana J. van Ballegooijen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background and aims: Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM).

Methods and results: We included 778 participants from the Hoorn Study (aged 68.4 +/- 7.2 years, 49% women), a population-based prospective cohort study, oversampled for people with impaired glucose metabolism or T2DM. Self-reported alcohol consumption was collected at baseline with a validated food-frequency questionnaire and categorized into: none (0/week), light (>0-30-70-140 g/week). Echocardiography was performed at baseline (N = 778) and after 8 years follow-up (N = 404). Multiple linear regression was used to study the association between alcohol consumption and echocardiographic measures (left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI)), adjusted for confounders. Moderate and heavy alcohol consumption were associated with a decreased LVEF of -3.91% (CI: -7.13;-0.69) for moderate and -4.77% (-8.18;-1.36) for heavy drinkers compared to light drinkers. No associations were found between alcohol consumption, LVMI and LAVI. Modified Poisson regression showed a trend that higher alcohol consumption amounts were associated with a higher risk of incident systolic dysfunction (LVEF

Conclusion: The findings provide longitudinal evidence that moderate and heavy alcohol consumption are associated with decreased LVEF and trend towards a higher risk of incident LV systolic dysfunction, compared to light drinkers. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalNutrition Metabolism and Cardiovascular Diseases
Issue number1
Publication statusPublished - 3 Jan 2020


  • Alcohol consumption
  • Epidemiology
  • Life style
  • Echocardiography
  • Heart failure
  • Glucose metabolism disorders
  • RISK


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