Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

Sabine van Oort; Joline W. Beulens; Amber A. W. A. van der Heijden; Petra J. M. Elders; Coen D. A. Stehouwer; Inge A. T. van de Luitgaarden; Ilse C. Schrieks; Diederick E. Grobbee; Adriana J. van Ballegooijen

doi:10.1016/j.numecd.2019.09.021

Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

Sabine van Oort^*, Joline W. Beulens, Amber A. W. A. van der Heijden, Petra J. M. Elders, Coen D. A. Stehouwer, Inge A. T. van de Luitgaarden, Ilse C. Schrieks, Diederick E. Grobbee, Adriana J. van Ballegooijen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and aims: Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM).

Methods and results: We included 778 participants from the Hoorn Study (aged 68.4 +/- 7.2 years, 49% women), a population-based prospective cohort study, oversampled for people with impaired glucose metabolism or T2DM. Self-reported alcohol consumption was collected at baseline with a validated food-frequency questionnaire and categorized into: none (0/week), light (>0-30-70-140 g/week). Echocardiography was performed at baseline (N = 778) and after 8 years follow-up (N = 404). Multiple linear regression was used to study the association between alcohol consumption and echocardiographic measures (left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI)), adjusted for confounders. Moderate and heavy alcohol consumption were associated with a decreased LVEF of -3.91% (CI: -7.13;-0.69) for moderate and -4.77% (-8.18;-1.36) for heavy drinkers compared to light drinkers. No associations were found between alcohol consumption, LVMI and LAVI. Modified Poisson regression showed a trend that higher alcohol consumption amounts were associated with a higher risk of incident systolic dysfunction (LVEF

Conclusion: The findings provide longitudinal evidence that moderate and heavy alcohol consumption are associated with decreased LVEF and trend towards a higher risk of incident LV systolic dysfunction, compared to light drinkers. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	132-140
Number of pages	9
Journal	Nutrition Metabolism and Cardiovascular Diseases
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.numecd.2019.09.021
Publication status	Published - 3 Jan 2020

Keywords

Alcohol consumption
Epidemiology
Life style
Echocardiography
Heart failure
Glucose metabolism disorders
HEART-FAILURE
DIASTOLIC FUNCTION
BLOOD-PRESSURE
ATRIAL VOLUME
DYSFUNCTION
INDIVIDUALS
RISK

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10.1016/j.numecd.2019.09.021

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van Oort, S., Beulens, J. W., van der Heijden, A. A. W. A., Elders, P. J. M., Stehouwer, C. D. A., van de Luitgaarden, I. A. T., Schrieks, I. C., Grobbee, D. E., & van Ballegooijen, A. J. (2020). Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study. Nutrition Metabolism and Cardiovascular Diseases, 30(1), 132-140. https://doi.org/10.1016/j.numecd.2019.09.021

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title = "Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study",

abstract = "Background and aims: Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM).Methods and results: We included 778 participants from the Hoorn Study (aged 68.4 +/- 7.2 years, 49% women), a population-based prospective cohort study, oversampled for people with impaired glucose metabolism or T2DM. Self-reported alcohol consumption was collected at baseline with a validated food-frequency questionnaire and categorized into: none (0/week), light (>0-30-70-140 g/week). Echocardiography was performed at baseline (N = 778) and after 8 years follow-up (N = 404). Multiple linear regression was used to study the association between alcohol consumption and echocardiographic measures (left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI)), adjusted for confounders. Moderate and heavy alcohol consumption were associated with a decreased LVEF of -3.91% (CI: -7.13;-0.69) for moderate and -4.77% (-8.18;-1.36) for heavy drinkers compared to light drinkers. No associations were found between alcohol consumption, LVMI and LAVI. Modified Poisson regression showed a trend that higher alcohol consumption amounts were associated with a higher risk of incident systolic dysfunction (LVEFConclusion: The findings provide longitudinal evidence that moderate and heavy alcohol consumption are associated with decreased LVEF and trend towards a higher risk of incident LV systolic dysfunction, compared to light drinkers. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.",

keywords = "Alcohol consumption, Epidemiology, Life style, Echocardiography, Heart failure, Glucose metabolism disorders, HEART-FAILURE, DIASTOLIC FUNCTION, BLOOD-PRESSURE, ATRIAL VOLUME, DYSFUNCTION, INDIVIDUALS, RISK",

author = "{van Oort}, Sabine and Beulens, {Joline W.} and {van der Heijden}, {Amber A. W. A.} and Elders, {Petra J. M.} and Stehouwer, {Coen D. A.} and {van de Luitgaarden}, {Inge A. T.} and Schrieks, {Ilse C.} and Grobbee, {Diederick E.} and {van Ballegooijen}, {Adriana J.}",

note = "Funding Information: IS and JB received a grant from the NIH [ U10 AA025286 ]. Funding Information: This work was supported by the Dutch Diabetes Research Foundation [ 2005.00.010 , 2003.01.004 ] and the Dutch Heart Foundation . SO and IL were partly funded by the NIH [U10 AA025286]. The funding sources had no role in the conduct of the research and/or preparation of the article. Publisher Copyright: {\textcopyright} 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University",

year = "2020",

month = jan,

day = "3",

doi = "10.1016/j.numecd.2019.09.021",

language = "English",

volume = "30",

pages = "132--140",

journal = "Nutrition Metabolism and Cardiovascular Diseases",

issn = "0939-4753",

publisher = "ELSEVIER SCI LTD",

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van Oort, S, Beulens, JW, van der Heijden, AAWA, Elders, PJM, Stehouwer, CDA, van de Luitgaarden, IAT, Schrieks, IC, Grobbee, DE & van Ballegooijen, AJ 2020, 'Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study', Nutrition Metabolism and Cardiovascular Diseases, vol. 30, no. 1, pp. 132-140. https://doi.org/10.1016/j.numecd.2019.09.021

Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study. / van Oort, Sabine; Beulens, Joline W.; van der Heijden, Amber A. W. A. et al.
In: Nutrition Metabolism and Cardiovascular Diseases, Vol. 30, No. 1, 03.01.2020, p. 132-140.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction

T2 - The Hoorn Study

AU - van Oort, Sabine

AU - Beulens, Joline W.

AU - van der Heijden, Amber A. W. A.

AU - Elders, Petra J. M.

AU - Stehouwer, Coen D. A.

AU - van de Luitgaarden, Inge A. T.

AU - Schrieks, Ilse C.

AU - Grobbee, Diederick E.

AU - van Ballegooijen, Adriana J.

N1 - Funding Information: IS and JB received a grant from the NIH [ U10 AA025286 ]. Funding Information: This work was supported by the Dutch Diabetes Research Foundation [ 2005.00.010 , 2003.01.004 ] and the Dutch Heart Foundation . SO and IL were partly funded by the NIH [U10 AA025286]. The funding sources had no role in the conduct of the research and/or preparation of the article. Publisher Copyright: © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University

PY - 2020/1/3

Y1 - 2020/1/3

N2 - Background and aims: Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM).Methods and results: We included 778 participants from the Hoorn Study (aged 68.4 +/- 7.2 years, 49% women), a population-based prospective cohort study, oversampled for people with impaired glucose metabolism or T2DM. Self-reported alcohol consumption was collected at baseline with a validated food-frequency questionnaire and categorized into: none (0/week), light (>0-30-70-140 g/week). Echocardiography was performed at baseline (N = 778) and after 8 years follow-up (N = 404). Multiple linear regression was used to study the association between alcohol consumption and echocardiographic measures (left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI)), adjusted for confounders. Moderate and heavy alcohol consumption were associated with a decreased LVEF of -3.91% (CI: -7.13;-0.69) for moderate and -4.77% (-8.18;-1.36) for heavy drinkers compared to light drinkers. No associations were found between alcohol consumption, LVMI and LAVI. Modified Poisson regression showed a trend that higher alcohol consumption amounts were associated with a higher risk of incident systolic dysfunction (LVEFConclusion: The findings provide longitudinal evidence that moderate and heavy alcohol consumption are associated with decreased LVEF and trend towards a higher risk of incident LV systolic dysfunction, compared to light drinkers. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

AB - Background and aims: Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM).Methods and results: We included 778 participants from the Hoorn Study (aged 68.4 +/- 7.2 years, 49% women), a population-based prospective cohort study, oversampled for people with impaired glucose metabolism or T2DM. Self-reported alcohol consumption was collected at baseline with a validated food-frequency questionnaire and categorized into: none (0/week), light (>0-30-70-140 g/week). Echocardiography was performed at baseline (N = 778) and after 8 years follow-up (N = 404). Multiple linear regression was used to study the association between alcohol consumption and echocardiographic measures (left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI)), adjusted for confounders. Moderate and heavy alcohol consumption were associated with a decreased LVEF of -3.91% (CI: -7.13;-0.69) for moderate and -4.77% (-8.18;-1.36) for heavy drinkers compared to light drinkers. No associations were found between alcohol consumption, LVMI and LAVI. Modified Poisson regression showed a trend that higher alcohol consumption amounts were associated with a higher risk of incident systolic dysfunction (LVEFConclusion: The findings provide longitudinal evidence that moderate and heavy alcohol consumption are associated with decreased LVEF and trend towards a higher risk of incident LV systolic dysfunction, compared to light drinkers. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

KW - Alcohol consumption

KW - Epidemiology

KW - Life style

KW - Echocardiography

KW - Heart failure

KW - Glucose metabolism disorders

KW - HEART-FAILURE

KW - DIASTOLIC FUNCTION

KW - BLOOD-PRESSURE

KW - ATRIAL VOLUME

KW - DYSFUNCTION

KW - INDIVIDUALS

KW - RISK

U2 - 10.1016/j.numecd.2019.09.021

DO - 10.1016/j.numecd.2019.09.021

M3 - Article

C2 - 31672450

SN - 0939-4753

VL - 30

SP - 132

EP - 140

JO - Nutrition Metabolism and Cardiovascular Diseases

JF - Nutrition Metabolism and Cardiovascular Diseases

IS - 1

ER -