Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis

J. M. T. Keijsers*, C. A. D. Leguy, A. J. Narracott, J. Rittweger, F. N. van de Vosse, W. Huberts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter. (C) 2017 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)143-159
Number of pages17
JournalJournal of Computational Science
Volume24
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Regulation of vascular tone
  • Metabolic regulation
  • Myogenic regulation
  • Baroreflex
  • 1D pulse wave propagation
  • IMMEDIATE EXERCISE HYPEREMIA
  • WAVE-PROPAGATION MODEL
  • MATHEMATICAL-MODEL
  • BLOOD-FLOW
  • INTRACRANIAL-PRESSURE
  • RAPID VASODILATION
  • AUTOREGULATION
  • CIRCULATION
  • DYNAMICS
  • HUMANS

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