Model-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation

Swantje Voller*, Robert B. Flint, Leo M. Stolk, Pieter L. J. Degraeuwe, Sinno H. P. Simons, Paula Pokorna, David M. Burger, Ronald de Groot, Dick Tibboel, Catherijne A. J. Knibbe, DINO Study Grp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)S90-S97
Number of pages8
JournalEuropean Journal of Pharmaceutical Sciences
Volume109
DOIs
Publication statusPublished - 15 Nov 2017

Keywords

  • Neonates
  • Population pharmacokinetics
  • Phenobarbital
  • Dose
  • YOUNG INFANTS
  • PHARMACOKINETICS
  • SEIZURES
  • CHILDREN
  • BIOAVAILABILITY
  • PREDICTION
  • PHENYTOIN
  • PRETERM
  • NEWBORN
  • WEIGHT

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